Objectives To determine the frequency of raised Urinary Trypsinogen-2 in diagnosed patients of acute pancreatitis. Methodology Settings Patients in emergency refer to General Surgery ward-3 Jinnah Post Graduate and Medical Centre Karachi. Duration Six months, started from 20-01-2012 to 19-07-2012. Study Design Cross sectional descriptive study. Subjects and Methods All cases of Acute Pancreatitis diagnosed by Upper Abdominal Pain, Raised Serum Amylase and/or Serum Lipase and Abdominal CT Scan findings, were included in the study. Urinary Trypsinogen-2 dipstick test was done. All patient related data including age, gender, sex and raised Urinary Trypsinogen-2 or normal, was recorded. Data analysis was done on SPSS version 10. Frequency and percentage was calculated for gender and raised trypsinogen-2. Age and gender wise stratification was done to see the effect of these variables on outcome. Results Mean age of the patients was 38.14 ±7.42 years. The minimum age was 24 years, while the maximum age was 63 years. Raised urinary trypsinogen-2 level was present in 55 (65.5%) patients. Stratification of age group shows, that 40 (66.7%) patients in age group ≤ 40 years had raised urinary trypsinogen-2. Stratification of gender showed significant association with raised urinary trypsinogen-2 level (p-value 0.010). Conclusion The frequency of raised Urinary Trypsinogen-2 in diagnosed patients of acute pancreatitis was found to be high.
The process of transplantation is accompanied by many complicated factors, each of which may be the cause of unsuccessful or failure in organ transplantation. Recently, we described the ultrastructural features of isolated is lets from the bovine pancreas. The present study deals with the comparative aspects of the isolated is lets from rat, pig and human pancreata. Rat pancreas was collected in the laboratory; pigmaterial was obtained from the local abattoir, and human pancreata were taken from biopsy material during surgical operation. The collected material was processed according to a recently described method in combination with the digestion-filtration technique, then further prepared for light- and electron microscopical investigations by fixation in 2% glutaraldehyde in 0.135 M phosphate buffer, 7.2 pH. After osmification (1% OsO4 in phosphate buffer) they were washed and dehydrated in acetone and embedded in Durcupan AMC. Semithin sections (0.5μm to 1.0μm) were used for light microscopical studies and ultrathin sections for electron microscopical observations.
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