Aging is a developmental process occurring in all living organisms after reaching a critical developmental stage, characterized by progressive loss of functions until death. Different cells/tissues age differently depending on epigenetics and cell-cell interactions. While males maintain fertility for the most part of their life females only maintain reproductive ability for a short time compared with their lifespan. The interesting question is why and how the females lose fertility so quickly. There have been many hypotheses proposed from different perspectives and recent research has revealed unusual interactions between germ cells and somatic cells which may determine the lifespan of reproduction in the females. This review briefly discusses recent progress in reproductive aging in the well studied model, C. elegans, and focuses on the molecular mechanisms which may be conserved across all animals including humans. aging, females, oocytes, lifespan, growth factors, mTOR Citation:Deng M Q. Mechanisms of reproductive aging in the females. Sci China Life Sci, 2012, 55: 653 -658,
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.