The interaction of triazole substituted 4-methyl-7-hydroxycoumarin derivatives (CUM1-4) with serum albumin (bovine serum albumin [BSA] and human serum albumin[HSA]) have been studied employing ultraviolet-visible (UV-Vis), fluorescence, circular dichroism (CD) spectroscopy, and molecular docking methods at physiological pH 7.4.The fluorescence quenching occurred with increasing concentration of CUMs, and the binding constant of CUM derivatives with BSA and HSA obtained from fluorescence quenching experiment was found to be~10 4 L mol −1 . CD study showed conformational changes in the secondary structure of serum albumin upon titration of CUMs.The observed experimental results were further validated by theoretical studies involving density functional theory (DFT) and molecular docking. K E Y W O R D S circular dichroism, coumarin, fluorescence quenching, molecular docking, serum albumin
Aiming at importance of virtual instruments in the field of Digital Signal Processing, a digital IIR Filter system is developed using National Instruments (NI) data LabVIEW software package. All the types of IIR filters like Butterworth filters, Chebyshev filters, inverse Chebyshev filters, and Elliptic filters are designed to generate their magnitude response and filter coefficients. The LabVIEW software is used to develop virtual instrument (VI) that includes a front panel and a functional diagram. The VI reads the desired parameters of the filters entered by the user on the front panel and determines its magnitude response and filter coefficients.
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