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The interaction of triazole substituted 4-methyl-7-hydroxycoumarin derivatives (CUM1-4) with serum albumin (bovine serum albumin [BSA] and human serum albumin[HSA]) have been studied employing ultraviolet-visible (UV-Vis), fluorescence, circular dichroism (CD) spectroscopy, and molecular docking methods at physiological pH 7.4.The fluorescence quenching occurred with increasing concentration of CUMs, and the binding constant of CUM derivatives with BSA and HSA obtained from fluorescence quenching experiment was found to be~10 4 L mol −1 . CD study showed conformational changes in the secondary structure of serum albumin upon titration of CUMs.The observed experimental results were further validated by theoretical studies involving density functional theory (DFT) and molecular docking. K E Y W O R D S circular dichroism, coumarin, fluorescence quenching, molecular docking, serum albumin

A new charge‐control model for the microwave characteristics of an AlGaAs/InGaAs/InP HEMT of 70 nm gate length has been developed. The threshold voltage has been modified by the inclusion of mole fraction and thermal effects. The current voltage characteristics have been obtained and compared with the 70 nm gate length device. In order to avoid short‐channel effects, an aspect ratio (gate length to gate to channel distance) larger than 5 is maintained in the analysis. The small‐signal microwave parameters (gm, gd) have also been evaluated. 2‐D analysis has been carried out in the saturation region. The unity gain cut‐off frequency of the order of 220 GHz is obtained at a gate length of 70 nm. Device parameters so obtained were used to calculate the hemt Y‐parameters. The Y‐parameters hold from the threshold region to the edge of saturation. The unilateral gain so obtained from the Y‐parameters yield a closer fit to the numerical model. All the results have been compared with the experimental data and show a close agreement and the validity of our model. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2462–2470, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22779

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Aiming at importance of virtual instruments in the field of Digital Signal Processing, a digital IIR Filter system is developed using National Instruments (NI) data LabVIEW software package. All the types of IIR filters like Butterworth filters, Chebyshev filters, inverse Chebyshev filters, and Elliptic filters are designed to generate their magnitude response and filter coefficients. The LabVIEW software is used to develop virtual instrument (VI) that includes a front panel and a functional diagram. The VI reads the desired parameters of the filters entered by the user on the front panel and determines its magnitude response and filter coefficients.