In this paper, we fabricated rutin-loaded silver nanoparticles (Rutin@AgNPs) as the nano-anticoagulant with antithrombotic function. The serum stability, anticoagulation activity, and bleeding risk of Rutin@AgNPs were evaluated. The results showed Rutin@AgNPs had good serum stability, hemocompatibility, and cytocompatibility. The anticoagulation activity of rutin was maintained, and its stability and aqueous solubility were improved. The Rutin@AgNPs could provide a sustained release to prolong the half-life of rutin. The results of the coagulation parameter assay and thrombus formation test in mice model showed that the activated partial thromboplastin time and prothrombin time were prolonged, and Rutin@AgNPs inhibited the thrombosis in the 48 h period. Moreover, the limited bleeding time indicated that the Rutin@AgNPs significantly minimized the hemorrhage risk of rutin. This Rutin@AgNPs is a potential anticoagulant for antithrombotic therapy.
The contradiction between energy supply and demand, environmental protection, and economic development is becoming more and more obvious. How to coordinate and balance the relations between energy, environment, and economy has become a common concern of scholars. In this context, the Energy-Environment-Economy (3E) system is gradually maturing, and up to now, the 3E system has been widely used in the evaluation of the development of various regions. In order to make the 3E system closer to the real social situation in the application, the measured results have more practical significance. Based on the new human capital theory, this paper summarizes and analyzes the relevant research literature, and discusses the influence of population on the three subsystems of energy, economy, and environment in the 3E system. It is found that population has an impact on each subsystem, among which it is worth noting that the impact of population on the environmental subsystem is diverse and complex, so the current situation of the 3E system is different from the theory. The article examines the impact of population on the 3E system in order to optimize and complement the 3E system.
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