For several decades, many drug types, including tablets, capsules, pills, creams, ointments, liquids, injectables, have been used for the treatment of disease. These dosage forms must be taken multiple times a day to maintain the concentration of the medication. Transdermal drug delivery systems (TDDS), also known as “patches,” are dosage forms Built to deliver a therapeutically efficient quantity of medicine through the skin of a patient. By increasing patient compliance and preventing first pass metabolism, transdermal delivery offers a leading edge over injectables and oral routes. Transdermal drug delivery provides the patient with controlled release of the drug, allowing for a stable blood level profile, leading to decreased systemic side effects and often increased effectiveness over other types of dosage. The primary objective of the transdermal drug delivery system is to deliver drugs with minimal inter-and intrapatient variations into systemic circulation via the skin at a fixed rate.To address the difficulties of drug distribution, primarily oral routes, the transdermal drug delivery system was implemented. Modifications of the materials used were mainly limited to refinements. The present review paper discusses the overall research on the transdermal drug delivery system (TDDS) leading to the current drug delivery system (NDDS). We used convectional dosage method earlier, but we are now using a novel system of drug delivery. The transdermal patch is one of the biggest advances in the delivery of new medicines. The value of the transdermal drug delivery system is that it is a painless drug administration procedure. There are variables that influence the bioavailability of transdermal products. Such as physiochemical and biological factors. Iontophoresis, phonophoresis, electroporation and micro needles, etc, are many new techniques that have drawn interest due to technological development.
Objective: The aim of the present study was to prepare and optimize levamisole chewable tablets by using various super disintegrants, namely; sodium starch glycolate, DRC Indion 204, and DRC Indion 234. Methods: Drug excipient compatibility study was carried out by FTIR spectroscopy to verify the compatibility of levamisole with the excipients. Nine batches of levamisole chewable tablets were prepared according to 32 factorial designs using a direct compression method by optimizing the super disintegrant concentration. The powder blend was exposed to pre-compression studies of the powder blend followed by post-compression studies of the formulated tablets. Results: FTIR study revealed that the excipients used in the formulations were compatible with the drug. The pre-compression and post-compression parameters were found within the IP limits. Form the dissolution studies, it was evident that the formulation prepared with DRC Indion 234 (50 mg) showed maximum percentage drug release in 45 min (97.13%) hence it is considered as optimized formulation. When compared to all other formulation, the batches with DRC Indion 234 (F7-F9) showed a better release of the drug (90 % drug release within 45 min). Conclusion: Nine batches of levamisole chewable tablets were successfully formulated by optimizing the concentration of super disintegrants such as sodium starch glycolate, DRC Indion 204, and DRC Indion 234. It was concluded from the dissolution studies that the DRC Indion 234 is the best super disintegrant irrespective of their concentration for the formulation of levamisole chewable tablets when compared to sodium starch Glycolate and DRC Indion 204.
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