A straightforward and efficient introduction of α-aminophosphonate moiety on Tröger's base is described for the first time. A two step preparation route involving, the formation of imines from the coupling of Tröger's base di-aldehyde with various amines followed by conversion of the imines to bis(α-aminophosphonates) using triethyl phosphite and chlorotrimethylsilane (TMSCl). The products were obtained in enhanced yields in comparison with one-pot Kabachnik-Fields approach.
Das Adamantylamino‐trimethyl‐silan (I) reagiert mit Butyllithium und der Verbindung ( II) über die Zwischenstufe (III) zur gesuchten Organo‐Phosphorverbindung (IV).
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