Science of Ayurveda was introduced with the Branch of Rasasastra from 3 rd century onwards. Rasasastra is a pharmaceutical branch of Indian Systems of medicine which mainly deals with Metals, Minerals, Animal origin products, Toxic herbs and their use in therapeutics. These rasa dravyas are found to have instant effectiveness, minimal dose and extensive therapeutic utility irrespective of constitutional variation. After the development of Rasasastra, inclusion of many herbo mineral preparations can be noticed in the Ayurveda books. Kravyada rasa is one such formulation seen in latest books of Ayuveda with a unique blend of herbal and mineral drugs which is fortified by subjecting to bhaavana (levigation.) in different media. Kravyada rasa is indicated in context of Agni mandhya or Mandaagni or Ajeerna adhikara. The formulation includes Parada, Gandhaka,Loha bhasma, Tamra bhasma,Tankana, Vida lavana and Maricha subjected to levigation. in Jambira juice ,Panchakola kwatha,Amlavetasa and Chanakamla. Formulation is also unique in its preparation as Kajjali along with Tamra bhasma and Loha bhasma is made into Parpati (thin flake like) and then subjected to repeated levigation. after adding remaining ingredients. In this study an attempt is made to gather information on Kravyada rasa from various classics with insight into ingredients, dosage and mode of action, thereby enabling further studies on Kravyada rasa; a less exploited herbomineral formulation.
Standardization is the process for the establishment of standard for a particular or drug. Standardization in Ayurvedic formulation mainly deals with ensuring standards for the quality and purity of raw materials, quality control during the drug manufacturing process, production of a good quality finished product and storage and distribution to maintain the quality of the final product. Standard of an Ayurvedic product can be assessed only by analyzing the analytical parameters of raw drugs, drugs after preprocessing and the finished products. Krimighatini vati explained in Rasendra chintamani is an antihelminth preparation explained in Rasendra Chintamani krimirogadhikara. It contains Parada- 1part, Gandhaka- 2 parts, Ajamoda -3 parts, Vidanga bheeja- 4 parts, Palaasha bheeja- 5parts, and Kaarsakara beeja- 6 parts. It is similar to Krimimudgara rasa that is available in market but differs in proportion of Palaasha beeja and Karaskara beeja. Present study aims to standardize Krimighatini vati after preparing the medicine according to the method explained in Ayurveda samhithas. Preprocessing of the Gulika includes, Shodhana of Hingula, Gandhaka and Karaskara beeja according to the methods mentioned in Rasasastra books. Parada was extracted from Hingula by Ordhwapaathana vidhi. It was then triturated with Shuddha Gandhaka to get Kajjali. Fine powders of other drugs were mixed with Kajjali and rolled into pills with Honey. Study observed the physicochemical parameters of individual drugs and validated the Gulika by HPTLC method. Analysis of Kajjali was done using XRD so as to prove the complete formation of Kajjali. Pharmaceutical standardization helps in reproducibility of drug paving way for more studies on toxicity and efficacy of drug.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.