Brain imaging studies have shown that progressive cerebral atrophy characterized the development of Alzheimer's Disease (AD). The key question is howAlzheimer's disease (AD) is the most prevalent form of dementia in persons older than 65 years [1]. Cognitive impairment, mainly related to memory deficits, is the most common manifestation of this disease [2]. Available neuroimaging evidence suggests that the neuropathological alterations underlying AD probably begin much * Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wpcontent/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf not peer-reviewed)
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