This retrospective study was done to determine the incidence of neonatal Group B streptococcal sepsis among newborn between 1998 and 2010. Among 107,692 babies born during this period, the overall incidence of Group B streptococcal sepsis was 0.76/1000 live births with the incidence of early onset sepsis being 0.68 (95% confidence interval: 0.52-0.83)/1000 live births. The overall rate of early onset sepsis decreased to 0.55/1000 live births with introduction of intrapartum antibiotic policy.
Hyperinsulinemic hypoglycemia is the most common cause of persistent hypoglycemia in infancy. While most of the cases are sporadic more than 100 mutations have been reported in the familial type. The authors report a case of familial hyperinsulinemic hypoglycemia with homozygous T294M mutation of the KCNJ11 gene, which responded to diazoxide therapy.
PURPOSE: To determine, the epidemiological characteristics and risk factors predisposing to fungal keratitis in Hubli, south India. To know the importance of KOH wet mount for rapid detection of fungal keratitis for institution of antifungal therapy as earliest possible. To know the statistical significance regarding the common type of fungi that involves the cornea and prognosis with regard to the available mode of therapy and their results. METHOD: In one year period, out of 112 patients presented with corneal ulcer, 48 (42.85%) were clinically suspected as having mycotic keratitis. Sensitivity of KOH wet mount preparation in our study is 96.25% in our study. Fusarium (53.84%) was most commonly isolated fungus. In our study all 48 cases were treated with Monotherapy, in that 28 cases patients deep stromal involvement were treated with combined therapy. About 15 patients received surgical treatment. 17(35.41%) cases had only HM positive and one case (2.08%) with only perception of light. and 2(6.25%) cases with no perception and rest had fairly good vision. CONCLUSION: These findings have important public health implications for the early diagnosis in suspected cases of mycotic keratitis and institution of specific therapy at earliest to avoid hazardous effects on cornea.
INTRODUCTION:corneal blindness accounts for 20-30 % of all blindness in developing countries of the world. Suppurative keratitis is the leading cause with mycotic keratitis constituting half of the cases in north Karnataka. Morbidity in mycotic infection tends to be higher compared to bacterial keratitis because diagnosis is often delayed due to negligence towards ocular trauma, inappropriate treatment and wide spread use of topical antibiotics and steroids for any case of corneal ulcer.KIMS Hubli, being tertiary care hospital and major referral center, we get more than twothree cases of mycotic keratitis per OPD. Considering its prevalence it is thought worthwhile to take up clinical study of mycotic keratitis to diagnose the case on suspicion with laboratory investigation and to start antimycotic treatment early for better results.
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