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Purpose-To determine the associations between nocturia and sleep disorders in perimenopausal women.Material and Methods-100 women with nocturia were compared to 200 women without nocturia. The presence of obstructive sleep apnea, insomnia, anxiety and menopausal stage were assessed using validated questionnaires. Comorbidities associated with nocturia were determined by bivariable analysis and multivariable logistic regression.Results-Independent associations for nocturia were anxiety (OR 2.11, 95%CI 1.08,4.13), African American race (OR 2.00, 95%CI 1.06,3.85), obstructive sleep apnea (OR 1.73, 95%CI 1.18,2.53) and insomnia (OR 1.11, 95%CI 1.05,1.12).Conclusion-Nocturia is associated with sleep disorders in perimenopausal women.

Objective: To estimate the relationship between changes in estradiol levels over time and lower urinary tract symptoms in premenopausal women as they transition to menopause. Methods: A self-administered validated questionnaire to measure lower urinary tract symptoms was administered to 300 women at the 11th assessment period on an ongoing longitudinal Penn Ovarian Aging cohort study. The association between the change in estradiol over time through the menopausal transition and lower urinary tract symptoms (urinary incontinence, filling symptoms, voiding dysfunction) was determined. Risk factors associated with lower urinary tract symptoms were determined by univariable analysis and multivariable linear regression. Results: Estradiol levels and menopausal stage at one point in time were not associated with lower urinary tract symptoms. Women with a sharp decline in estradiol levels over time had significantly lower urinary incontinence scores in comparison to women without a change in estradiol levels through the study period (3.11 ± 2.86 vs 2.08 ± 2.43, adjusted mean difference=−0.93, 95%CI: −1.8,−0.02). Women between the ages of 45 to 49 had significantly higher urinary incontinence scores than women woman age > 55 (1.59 ± 1.86 vs 3.04 ± 2.93, adjusted mean difference= 1.0, 95%CI: 0.01, 2.1). Women with a BMI greater than 35 also had significantly higher urinary incontinence scores than women in the normal weight range, (3.53 ± 3.16 vs 1.98 ± 2.52, adjusted mean difference=1.5, 95%CI: 0.59, 2.3) after adjusting for changes of estradiol through the menopausal transition. High anxiety was associated with worsening scores in all three lower urinary tract symptoms domains (incontinence, filling, voiding). Conclusion: Women with a sharp decline in estradiol through the menopausal transition have significantly lower urinary incontinence scores. Urinary filling symptoms and voiding dysfunction were not associated with changes in estradiol through the menopausal transition.

Female sexual dysfunction is associated with the presence of depression and urge urinary incontinence in women of low-income status living in an urban setting.