A mesoporous copper complex was synthesized with a novel double helix morphology and successfully utilized as a biomimetic catalyst for phenoxazinone synthase activity.

To develop the corrosion resistance and improve the biological performance of a titanium implant (Ti6Al4V alloy), a series of mineral (M = Zn and Mg)-substituted hydroxyapatite (MHA), chitosan-MHA (CS-MHA), halloysite nanotube-MHA (HNT-MHA), and HNT-CS-MHA composite coatings were fabricated on the anodized titanium alloy by electrodeposition. The surface morphology and cross section of various coated composites were investigated by high-resolution scanning electron microscopy (HR-SEM). Furthermore, the functional groups and phase structure of the composite coatings were investigated by Fourier transform infrared spectroscopy (FTIR) and X-ray diffractometry (XRD). Corrosion behaviors of the composite coatings were also investigated by polarization and impedance spectroscopy (EIS). Moreover, the cell-material interaction of the composite coating was observed in vitro with human osteoblast MG63 cells for cell proliferation at 1, 4, and 7 days of incubation. Consequently, HNT-CS-MHA-Ti may have potential applications in the field of orthopedic and dental implants.

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Titanium and its alloys are of a great importance for the development of prosthetic materials in hard tissue replacements as well as in thebiomedical applications because of its excellent fabrication properties, lower cost, broader availability, good fatigue strength, high corrosion resistance, formability, machinability and bio-stability [1-4]. However, they show a poor osteointegration properties and cannot meet all of the clinical requirements such as inflammation, corrosion, wear, fracture toughness or low fatigue strength and mismatch in elastic modules between the implants and bone interface [5-7]. Therefore, in order to improve the chemical, biological properties, surface modification is often performed. It was also reported that coated materials such as TiO2, Al2O3, ZrO2 and hydroxyapatite (HA), possess an outstanding corrosion resistance, high chemical stability, mechanical properties when used as coating materials. In this case the implants are coated with bioactive materials like hydroxyapatite [Ca10(PO4)6(OH)2] (HA) for bone-cells activation and encouraging in-growth of natural bone into the prosthetic