An improved synthetic process has been developed for preparation of 4-[(3¢-chloro-4¢-fluorophenyl)amino]-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline(gefitinib) (X) from economically available starting material, 3-hydroxy-4-methoxybenzaldehyde (isovaniline) (I) through a sequence of simple reactions with readily available reagents. The additional advantages of this convenient synthetic approach are non-tedious work-up, high yield, and high purity without employing laborious and time-intensive column chromatography techniques.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.