Cbk1 kinase was previously implicated in regulating polarized morphogenesis, gene expression, and cell integrity. This study reveals that Cbk1 regulates heat shock signaling and stress adaptation by modulating Mpk1 activity and MAPK phosphatase localization. A model for Cbk1 and its putative substrate for these functions is presented.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.