Introduction: Chemoprevention refers to using specific substances during oncogenesis. Curcumin and catechins are both a polyphenol type of phytochemicals presents in curcuma longa and green tea. The effect of curcumin is synergistic with epigallocatechin gallate, the most abundant polyphenol in tea. Aim: To evaluates and compares the chemopreventive effect of both green tea and curcumin (each individually and in combination) through induction of hamster buccal pouch carcinoma. Materials and Methods: Squamous cell carcinoma was chemically induced in fifty Syrian golden hamsters divided into 5 groups (10 each). Results: The cells of positive control group (B) resulted in 11.57% apoptosis. In the study groups, treatment of the cells with green tea (C), curcumin (D) and both of them (E) showed increase apoptosis. The fluorescent image in group B showed increase of the red fluorescence in the nucleus and cytoplasm of the squamous cell carcinoma cells while in group C, D and E showed decrease of the red fluorescence in the nuclei of the squamous cell carcinoma cells. The microvessel density was higher in the positive control group as compared to the treated groups. Conclusions: The combination of green tea and curcumin has a significant chemopreventive effect against oral carcinogenesis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.