The hydration of α,β‐unsaturated ketones with water proceeded efficiently in the presence of In(OTf)3 (20 mol%) in aqueous media to afford synthetically versatile β‐hydroxyketones in moderate to good yields with good functional group compatibility. The method also can be extended to the hydroalkoxylation of α,β‐unsaturated ketones with various alcohols for the efficient synthesis of β‐alkoxyketones as well as tetrahydrofuran derivatives.magnified image
An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.
An efficient method for the synthesis
of alkyl indium reagent by
means of an iodine-catalyzed direct indium insertion into alkyl iodide
in THF is reported. The thus-generated alkyl indium reagents effectively
underwent Pd-catalyzed cross-coupling reactions with various aryl
halides, exhibiting good compatibility to a variety of sensitive functional
groups. By replacing THF with DMA and using 0.75 equiv of iodine,
less reactive alkyl bromide could be used as substrate for indium
insertion with equal ease.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.