Poucos estudos analisaram a qualidade de vida (QV) em populações específicas, como os profissionais da área de saúde. Avaliamos a QV por meio do Whoqol-bref em estudantes do primeiro (n = 50) e sexto (n = 50) anos do curso de Medicina. A pontuação média dos alunos do primeiro e sexto anos (escala de 0-100) em cada domínio foi, respectivamente, de 77,9 e 76,8 (físico), 71,1 e 72,6 (psicológico), 70,2 e 77,8 (relações sociais) e 67,7 e 70,1 (ambiental). Houve diferença estatística entre os dois grupos apenas no domínio das relações sociais (p <0,05). Nossos resultados demonstraram pontuações altas em todos os domínios do Whoqol-bref, indicando uma boa QV nos grupos estudados. Os alunos do primeiro ano estão se adaptando à nova vida acadêmica, o que provavelmente contribuiu para sua menor pontuação no domínio das relações sociais. Aproximadamente um terço dos alunos dos dois grupos pontuou dentro do primeiro quartil em três ou em todos os domínios, indicando aqueles com pior QV. Isto sugere que estes indivíduos devem receber maior atenção, para prevenir o risco de burnout descrito na literatura entre estudantes de Medicina.

Background: Melanin plays an important role in protecting the skin against the harmful effects of solar radiation, but its abnormal accumulation may become an aesthetic problem, such as melasma and age spots. Aims: The aim of this study was to evaluate the antiangiogenic and whitening effects of a depigmentation formulation (BLTX) using an in vitro model of human cell and skin culture. Methods: Human fibroblasts, keratinocytes or melanocytes were treated with BLTX and subjected to oxidative stress by UV radiation or inflammatory stress with IL-1α for quantification of melanin, tyrosinase, endothelin-1, PAR-2, VEGF and iNOS. Fragments of human skin, from elective plastic surgery, were treated with BLTX and subjected to histological evaluation with hematoxylin/eosin associated with Fontana-Masson technique for melanin view. A parametric method, the one-way analysis of variance (ANOVA) followed by the Bonferroni test, was used to compare data among all groups. Results: The results demonstrated that BLTX promotes a reduction in VEGF and iNOS protein synthesis in cultured dermal fibroblasts, indicating an antiangiogenic property. In relation to whitening effect, BLTX was able to reduce the production of melanin in both systems, melanocytes and human skin cultures. The depigmenting action was also revealed by decreasing the levels of endothelin-1, PAR-2 and activity of tyrosinase, when compared to cultures exposed to UV radiation. Conclusion: The results allow us to infer that BLTX presents an antiangiogenic effect indicating a role in the vascular component of melasma. Furthermore, the whitening property observed reinforces its use in the prevention and treatment of melasma.

Background: Mechanisms involved in hair metabolism are diverse, and the availability of ingredients that normalize dysfunctions or mitigate the effects of extrinsic stress suffered daily is greatly desired by consumers to improve the aesthetic appearance of hair. Aims:In this work, we carried out a preclinical exploratory approach to evaluate the effects of a complex of nanoencapsulated active ingredients (AcPi), as well as a cosmetic formulation containing AcPi (ShPi and HtPi) in mechanisms involving hair loss and follicular aging.Methods: Human hair follicle dermal papilla cells and human scalp culture were treated with AcPi, ShPi, or HtPi and stimulated with UV radiation or testosterone for further measurement of mitochondrial biogenesis, reactive oxygen species (ROS), β-catenin, dyhidrotestosterone (DHT), collagen XVIIα1 (COL17A1), and cutaneous permeation.Results: Our results demonstrated that AcPi prevents oxidative stress and balances mitochondial activity disturbed by exposure to UV radiation. AcPi also promoted an enrichment of WNT/β-catenin signaling pathway, stimulating hair growth, and lengthening the anagen phase of hair cycle. ShPi and HtPi were able to prevent hair aging, minimizing the excessive degradation of COL17A1 in hair follicle exposed to UV radiation, in addition to controlling androgenic metabolism by reducing DHT production. Conclusion:The integral effects of AcPi have not been completely elucidated; however, these results, associated with clinical evidences, allow us to infer that this ingredient prevents follicular aging, miniaturization, and consequently hair loss by mechanisms involving energetic homeostasis maintenance, antioxidant, and antiandrogenic actions. How to cite this article: Honda Igarashi M, da Silva SG, Mercuri M, et al. Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of WNT/signaling, mitochondrial activity, and stem cells maintenance.