Background: One of the most striving problem among coronary artery disease is ST elevated myocardial infarction. It is the infarction in which entire wall of coronary artery gets occluded and is associated with ST segment elevation (>2mm in atleast 2 chest leads or >1mm in precordial leads or limb leads) on ECG. The impact of Streptokinase and Tenecteplase on ECG and 2D-echo in patients with ST elevated myocardial infarction and the effect of timing of thrombolytic therapy were compared. Material and methods: Patients presented with chest pain within 12 hours diagnosed with st elevated myocardial infarction and received thrombolytic therapy is included in our study. Results: 40 patients were recruited for our study. 20 patients were excluded because of their advice to higher centres due to their critical condition and not available for follow up. ST elevated myocardial infarction patients who were taking streptokinase 1.5 million units and tenecteplase 40 mg completed the study. Among 20 patients 13 (65%) patients treated with streptokinase and 7 (35%) patients treated with tenecteplase. After 30 days follow up 2D echo reveals regional wall motion abnormalities in 10 patients of Streptokinase group and 2 patients of Tenecteplase group. Regional wall motion abnormalities was absent in 3 patients of Streptokinase group and 5 patients of Tenecteplase group. Conclusion: From this study we demonstrate that tenecteplase was more efficacious than streptokinase in terms of ECG readings (ST resolution), 2D-echo. Patients who were presented within 6 hours have benefited more.
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