No abstract

Background: Epilepsy has been considered as a public health problem by WHO and ILAE. It was felt that there remains considerable scope for the development of better epilepsy services in a developing country like India. Hence we sought to evaluate the drug utilization of antiepileptic drugs. Aim: The study was designed to evaluate the drug utilization of anti epileptic drugs in in-patient admission of medicine and pediatric departments at tertiary care teaching hospital. Methods: The data was obtained prospectively from 132 patients with antiepileptic drug over a period of 6 months. The utilization was assessed based on age, seizure type, therapy, newer and conventional AEDs and rationality of prescriptions. Results: AEDs are highly prescribed for an age group of 0-2 years in the study. AEDs are highly prescribed as monotherapy in 62.12% of the patients. In the study 51.5% of AED were prescribed alone and 40.62% of AED with add-on therapy of benzodiazepine and found statistically significant (P<0.005). Assessment of rationality was done as per ILAE and IAP guidelines of which 64% and 75.7% were found to be rational respectively. Conclusion: In the study, conventional AEDs are used as monotherapy was more effective in terms of reduction of seizures, as they are available at low costs and are more affordable than the newer drugs and polytherapy. The study concludes the effective use of benzodiazepines along with AED. Due to the lack of specific guidelines for the usage of AED in India, the rationality in the prescription is variable and poor.

No abstract

No abstract

Objectives:To evaluate the neuroprotective effect of Stereospermum suaveolens DC on 6-hydroxy dopamine induced Parkinson's disease model.Materials and Methods:The study was conducted on Sprague-Dawley rats where parkinson's disease was induced by producing the striatal 6-hydroxy dopamine lesions. The test animals received methanolic extract of Stereospermum suaveolens at dose of 125, 250 and 500 mg/kg for 42 days. Behavioral assessment, spontaneous locomotor activity and muscular coordination were studied. Antioxidant levels, striatal infraction area were assessed and histopathological studies were carried out.Results:The Stereospermum suaveolens DC methanolic extract showed significant dose dependent increase in behavioral activity, improved muscular coordination. Significant reduction of lipid peroxidation (LPO), increased antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT) and non-enzymatic activity of glutathione (GSH) and total thiol levels in extract treated groups was observed in test groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group.Conclusion:The methanolic extract of Stereospermum suaveolens DC showed neuroprotective activity against 6-hydroxy dopamine induced Parkinson's disease in rats.

Context: Stereospermum suaveolens DC. (Bignoniaceae) is a medicinal tree species native to India. Traditionally, the whole plant is used for various diseases including neuronal disorders. Objective: The present study evaluated the neuroprotective activity of Stereospermum suaveolens against global cerebral ischemia in a rat model. Materials and methods: Neuroprotective activity was carried out by global cerebral ischemia on Sprague-Dawley rats and divided into five groups of eight rats each; sham and control groups received normal saline (10 ml/kg) and treated groups received methanol extract of Stereospermum suaveolens (MES) orally (125, 250, and 500 mg/kg) for 10 days prior to the experiment. Global cerebral ischemia was induced by bilateral carotid artery (BCA) occlusion for 30 min followed by 4-h reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated by UV spectroscopic method along with cerebral infarction area; histopathological studies were carried out. Results: LD 50 of MES was found to be 5000 mg/kg of body weight. The entire test was performed at dose levels 125, 250, and 500 mg/kg of body weight. The results of the study indicate that the Stereospermum suaveolens methanol extract showed neuroprotective activity by a significant decrease in lipid peroxidation (p50.001) and an increase in superoxide dismutase (p50.01), catalase (p50.01), glutathione (p50.001), and total thiol (p50.001) levels in extract-treated groups as compared to control group. Measurement of cerebral infarction area and histopathological studies further supported the protective effect of the extract. Discussion and conclusion: These findings suggest a potential protective role of Stereospermum suaveolens against global cerebral ischemia/reperfusion-induced brain injury.

Background Plants have been proven to be offering a wide number of medicinal uses. Mimusops elengi plant is rich in phytoconstituents present almost in every part of the plant. Roots are the parts on which minimum work has been done.Objective The objective of the present study was a preliminary evaluation of physicochemical and free radical scavenging activity of Mimusops elengi L. root. Methods Many standardization parameters like extractive values total ash value water-soluble ash value and acid insoluble ash moisture content and loss on drying LOD of Mimusops elengi L. root were analyzed. The total phenolic content TPC and total flavonoid content TFC were measured. Free radical scavenging FRS activity was evaluated by assessing DPPH scavenging activity.Results The results of phytochemicals screening of hydroalcohol extract revealed the presence of various secondary metabolites including alkaloids flavonoids saponins sterols and tannins. The amount TPC and TFC were found to be 21.63plusmn0.0663 mg of gallic acid equivalent weightg of extract and 159.0 plusmn 0.9 mg of quercetin equivalent weight g of extract respectively. The extract showed potent FRS activity IC50 value of 96.13 microgmL.Conclusions The present study revealed Mimusops elengi L. Root contains most potent antioxidant agents and has significant FRS activity.nbsp

No abstract