The synthesis and anti‐HIV evaluation of hitherto unknown 3′‐fluoro‐5′‐norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4′ position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds was found to be an inhibitor of HIV‐1 replication, but with moderate efficiency relative to (R)‐9‐(2‐phosphonylmethoxypropyl)adenine ((R)‐PMPA, tenofovir), with no concomitant cytotoxicity.
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