The main objectives of this study were to evaluate the physicochemical parameters in the leachates of four plastic biomedical devices of 21 brands; including intravenous transfusion sets (IV sets, seven brands), dextrose normal saline bottles (DNS bottles, five brands), Ringer lactate bottles (RL bottles, five brands) and Ryle's tubes (four brands). The specimens used in the present study were purchased from five major cities of Uttar Pradesh, India, from approved medical shops. The observations revealed that there was no change in the physical state of plastic samples. The leachates of all the samples were odourless, clear and colourless. The pH of leachates was slightly altered at different simulating conditions and simulants. The maximum global migration residue was found from the leachates of IV tubing in 5% sodium carbonate (4.34 mg/100 ml) at 60 ± 2 C for 2 hours condition while the minimum was in the leachates of the DNS bottles in 3% acetic acid (0.11 mg/100 ml) at 4 ± 1 C for 72 hours condition. The maximum migration of oxidizable matters was found from the leachates of Ryle's tube in double distilled water (1.8 ml; difference in the volume of sodium thiosulphate consumed) while the minimum was found from the leachates of Ryle's tube in 0.9% sodium chloride (0.1 ml; difference in the volume of sodium thiosulphate consumed). The maximum migration of UV absorbing materials was found from IV tubing in 3% acetic acid Optical Density (OD-0.336) while the minimum was from DNS bottles in double distilled water (OD-0.058). Our present study also finds that the commercial plastic biomedical devices contain heavy metals such as Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn. Some of the heavy metals like Cd, Fe and Zn were found to be above permissible limits according to BIS (Bureau of Indian Standard) and International guidelines.
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