Our study aimed to assess active renin concentration in children with primary hypertension. Thus, we evaluated active renin concentration, clinical parameters, office and ambulatory blood pressure, and biochemical parameters in 51 untreated adolescents with primary hypertension (median: 14.4 [interquartile range—IQR: 13.8–16.8] years) and 45 healthy adolescents. Active renin concentration did not differ between patients with hypertension and healthy children (median: 28.5 [IQR: 21.9–45.2] vs. 24.9 [IQR: 16.8–34.3] [pg/mL], p = 0.055). In the whole group of 96 children, active renin concentration correlated positively with serum potassium and office and ambulatory systolic and diastolic blood pressures. Among children with hypertension, patients with isolated systolic hypertension had lower renin concentration than patients with systolic-diastolic hypertension (26.2 [IQR: 18.6–34.2] vs. 37.8 [IQR: 27.0–49.6] [pg/mL], p = 0.014). The active renin concentration did not differ between patients with isolated systolic hypertension and healthy children. In multivariate analysis, diastolic blood pressure Z-score (beta = 0.238, 95 confidence interval [0.018–0.458], p = 0.035) was the only predictor of active renin concentration in the studied children. We concluded that active renin concentration is positively associated with blood pressure and potassium in children, and diastolic blood pressure was the strongest predictor of renin level. Patients with isolated systolic hypertension may differ from patients with systolic-diastolic hypertension in less severe activation of the renin-angiotensin-aldosterone system.
Accurate and in-time monitoring of corrosion inhibitor (CI) residual concentration is a key factor in asset integrity management for oil and gas operations. However, the natural variability of CI residual due to field conditions is usually convoluted with the error introduced by sampling and analytical techniques. In traditional analytical techniques, it is typical to encounter error of over 100%. Recently, a novel nanoscale technique (TrueDetect™, TD) was developed to accurately measure CI in the field. This technique is based on a proprietary spectrometry technique and allows quick and accurate analysis of CI residual at the ppm level. The portable instrument allows field samples to be analyzed on-site without the need for shipping them to a centralized laboratory. In the current study, the TD technique was applied to analyze field samples from various fields. Moreover, the TD technique was capable of analyzing CIs at low dosages and could be used as a method to qualify CI products in the lab and in the field.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.