buffer capacity of the kidney is exceeded. 2 We suggest that in aPLA2R-negative patients PLA2R-related disease must be excluded either by staining of PLA2R in kidney biopsies or by renewed evaluation of serum after 6-month follow-up. 1. Debiec H, Ronco P. PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. N Engl J Med 2011; 364: 689-690. 2. Fresquet M, Jowitt TA, Gummadova J et al. Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy.
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