An accurate, simple, fast and cheap spectrophotometric method has been developed for the determination of lisinopril in pharmaceutical pure and dosage forms. The method is based on the reaction of Alizarin with primary amine present in the lisinopril in the presence of 80% ethyl alcohol. This reaction produces a complex Red colored product which absorbs maximally at 434 nm. Beer's law was obeyed in the range of 4.415-300.23 µg/mL with molar absorptivity of 1.619 × 10 3 L mole -1 cm -1 Sandell's sensitivity 0.272 µg.cm -2 . The effects of variables such as temperature, heating time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations..
Simple, accurate and highly sensitive spectrophotometric method has been developed for the rapid determination of dihydroergocryptine mesylate in pure form and pharmaceutical formulations. The spectrophotometric method was based on the formation of binary complex (ion-pair complex) between the dihydroergocryptine mesylate and chromotrope 2R in acidic buffer, giving purple color. The absorbance of dichloromethane extracted complex was measured at 531 nm. The effects of analytical parameters on the reported systems were investigated. The complexation reaction was extremely rapid at room temperature and the absorption value remains unchanged up to 24 h. Beer's law was obeyed in the concentration ranges of 3-180 µg/mL, detection limit was 0.08 µg/mL and the molar absorptivity coefficient were 6.8 × 10 3 L mol -1 cm -1 for chromotrope 2R. Recoveries were between 97.20-101.11 %. Interferences of the other ingredients and excipients were not observed.
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