Post rollout safety for the coronavirus disease vaccines is crucial and recommended. To explore the early solicited adverse events (AE) following BNT162b2 mRNA vaccination in Saudi Arabia, we distributed an online survey to adults vaccinated with BNT162b2 over the first week of June 2021, to collect data on first (V1), second doses (V2), symptoms, severity, and outcome after an informed consent was obtained. We recruited 3639 BNT162b2 vaccinated individuals, of which one-third had received two doses, 63.3% were female, 77% were healthy, and 89% had 18–55 years of age, while only 9.8% had a history of allergy. Overall, 50.3% had any AEs after any dose, especially those younger than 55 years of age, female, history of comorbidity, and when adjusted for age and gender, lung or cardiovascular diseases. Overall, the most common AE were pain at the injection site (44%), tiredness (39%), or body ache (31%). Compared to V1, a higher rate of post-V2 systemic AE (36% vs. 51%). Most AEs started very early (within 3 days), and rarely delayed in recovery (>2 weeks). Anti-pyretic was the most commonly used (51.7%), a third of which was unnecessary. Only 1.7% required hospital admission. By multivariate analysis, predictors for admission were the presence of lung or immunocompromising diseases. In conclusion, common AEs after BNT162b2 in the real world were generally mild, self-limiting, higher after the second dose, and largely mimicking that reported in clinical trials. The causality of these AE and the persistence of post-vaccination symptoms needs to be investigated further.

The interest in the use of complementary and alternative medicine (CAM) has been well documented. Knowledge, Attitude, and Practices (KAP) studies in CAM are critical for paving the way for intervention efforts to raise awareness. The aim was to measure the knowledge and attitudes of adults and to identify the factors associated with the use and practice of Complementary and Alternative Medicine (CAM) in Riyadh, Saudi Arabia. An observational cross-sectional, community-based, and multi-center study was conducted. After receiving consent, data were collected using a Google form-based online questionnaire. Most of the participants (82.5%) preferred to use CAM in combination with conventional medicine. The most common health problems were menstrual pain (49.5%) and abdominal pain (24.5%). The commonly used CAM remedies in this study were honey (65%) and Zamzam (Believed to be blessed holy water in the Islamic faith) (59.6%). The common causes given by the participants for preferring CAM remedies were because they were natural products (34%) and also avoiding the side effects of drugs (33.5%). Participants younger than 18 were the most supportive age group. Honey was the most chosen modality, contrary to the findings of the Qassim study. It was found that the common cold was the commonest reason for CAM use in the study's population, whereas in the Bahrain study diabetes mellitus was the reason. In conclusion, awareness about CAM was remarkably high among the participants of this study. A high proportion of respondents prefer to use CAM along with traditional medicines. The high proportion use of CAM encountered in this study was remarkable for the health education that addresses both advantages and drawbacks of CAM. Proper scientific research into safety and effectiveness is needed.