No abstract

We conducted a cross-sectional study to evaluate the role of serum levels of CA125 and HE4 in predicting optimal cytoreductive surgery. Eligible women who had been diagnosed with ovarian cancer based on both clinical and imaging criteria were enrolled in this study. Serum levels of CA 125 and HE4 were checked before surgery and all patients underwent complete surgical staging. After completion of the pathological evaluation, data were entered in SPSS version 23. One hundred and ten individuals were enrolled in our study. We divided cases between two groups: stage I to III b and stage IIIc to IV. Serum level of HE4 >170 pmol/L can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%) and serum level of CA 125 > 320 UI/mL can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%). Our data demonstrated a negative predictive value of about 80% for both HE4 and CA125. Based on these cut-off, unnecessary surgery can be avoided in many cases, however, it is unwise to ignore clinical performance and radiological findings. Nevertheless, we can say the evaluation of tumor markers is feasible and helpful in predicting optimal surgery.

No abstract

Introduction and Objective: Definitive diagnosis, tedious treatment methods, and long treatment duration are possible factors contributing to psychiatric disorders in cancerous patients, including anxiety and depression. Accordingly, this study aimed to investigate the effective factors on the occurrence of psychiatric disorders in newly diagnosed cancer patients. Methods: This descriptive-analytical study was conducted in Semnan, Iran, in 2018, in which 122 patients with cancer were included. In this study, the Hospital Anxiety and Depression Scale questionnaire was used to collect the required data. Frequency comparisons between the sub-groups were performed using the Chi-square test and, if necessary, Fisher’s exact test. Moreover, the T-test or Mann–Whitney U test was used to compare numerical variables. Results: In this study, the mean values of total depression and total anxiety among patients were 26.2% and 28.6%, respectively. According to the results, anxiety was observed in 74.3% of low-income people and 80% of females. Gender and income were significantly associated with anxiety in patients with cancer (p < 0/05). However, no significant association was found between depression and the variables of gender, age, level of education, and income (P > 0.05). Conclusion: The inclusion of psychiatric interventions in the treatment program of cancer patients can be effective in controlling psychiatric disorders, especially depression and anxiety.

The Article Abstract is not available.