High fat diet HFD induces excessive body fat content and lipid abnormalities. The importance of using medicinal plants becomes more patent in the present time Artichoke is a plant that traditionally used for treatment of different disease. The study aimed to investigate the role of supplementing low or high doses of water extract of artichoke leaves in rats fed HFD. For this purpose, four rat groups were established as follow: control group, high fat diet group, Low dose artichoke+ HFD group treated by low dose of artichoke extract(600 mg /kg b.w/day) after three weeks following obesity induction, and high dose artichoke +HFD rats was treated by high dose of artichoke extract(1500 mg /kg b.w /day). Body weight gain, serum lipid parameters, liver enzymes and liver histological status were examined. Results showed that HFD increased body weight, lipid parameters and causes abnormal liver enzyme levels along with fat droplets accumulation between liver cells. These parameters were counteracted by supplementing either low or high dose of artichoke extract, indicating the mitigating effect of artichoke against HFD side effects. It was noticed that the hypolipodemic and antiatherogenic effect was more observable in low dose of extract than that of high dose.
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