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Hospital-acquired Respiratory-Tract Infections (HARTIs) are identified as the most frequent type of hospital-acquired infections. They can engender significant morbidity and mortality rates, generating a heavy economic burden, especially in the limited resources countries. In this perspective, this study aimed to determine the prevalence of HARTIs in the University Hospitals (UHs) of Southern Tunisia and to identify their main associated factors. It was a cross-sectional study conducted in the two UHs of Sfax governorate, Tunisia, from July 10 to 24th, 2017, including all hospitalized patients for at least 48 hours. It was a 1-day pass per department and a 1-week survey per UH. In total, 34 cases of HARTIs were notified among 752 surveyed patients, accounting for an overall prevalence of 4.5%. The prevalence of HARTIs in the Intensive Care Units (ICU) was 20.6%. Multivariate logistic regression analysis showed that developing a HARTI in non-ICU was independently associated with tobacco use [Adjusted Odds Ratio (AOR) = 2.83; 95% Confidence Interval (95% CI) = [1.10-7.27]; p = 0.03], central vascular catheter (AOR = 5.70; 95% CI = [1. 29-25.15]; p = 0.022) and McCabe Index ≥1 (AOR = 7.38; 95% CI = [2. 73-19.97]; p < 0.001). In ICU, only endotracheal tube was independently associated with HARTIs (AOR = 42.5; 95% CI = [4.97-64.13]; p = 0.001). This study illustrated the extent of HARTIs problem threatening the quality of care in Southern Tunisia. Identifying the risk factors of HARTIs in both ICUs and non-ICUs may help healthcare workers to ascertain the avoidability of these infections.

Background: The aim of this study was to describe the epidemiological profile of childhood respiratory tract diseases (RTD) in the region of Sfax, Tunisia, and to evaluate their trends over a 13 year period. Methods: We conducted a retrospective study of all children hospitalized with RTD aged under 14 years. We collected data from the regional morbidity register of the university hospital of Sfax from 2003 to 2015.Results: A total of 10 797 RTD patients were enrolled from 49 880 pediatric hospitalizations (21.7%). A male predominance was noted (60%). The median age was 8 months (IQR, 2-36 months). Acute bronchitis (AB) accounted for 53.8%, followed by asthma (15%), pneumonia (14%) and acute upper respiratory infection (AURI; 7.2%). The hospital incidence rate (HIR) of RTD was 34/10 000 inhabitants/year. It was 18.2; 5.07; 4.7 and 2.4/10 000 inhabitants for AB, asthma, pneumonia and AURI, respectively. We noted a significant increase in the HIR of RTD with an annual percentage change (APC) of 10.94% (P < 0.001); in the HIR of AB (APC, 5.27%; P < 0.001); and in asthma HIR (APC, 11.2%; P < 0.001). Otherwise, a significant decrease in AURI HIR was observed (APC, -8.8%; P < 0.001). AB lethality rate increased significantly, with an APC of 7.4% (P < 0.001). Projected trends analysis up to 2024 showed a significant rise in AB and in asthma, while AURI would significantly decrease. Conclusions: RTD continues to be a serious health problem over time in terms of morbidity and mortality. Preventive and curative strategies are needed urgently.Key words hospital, pediatric, projection, respiratory tract disease, trend.Respiratory tract diseases (RTD) continue to be a serious health problem worldwide. They confer a significant economic burden with regard to the funding of health resources and disability care loads. Among children, RTD contribute to increase mortality and morbidity. Pediatric hospital morbidity studies allow us to determine the epidemiological profile of a population and to orient interventional strategies accordingly. In Tunisia, as in developing countries, RTD represent a challenge to public health because of their frequency, severity, projected trends, and economic impact. There have been persistently high rates of RTD, particularly of asthma and acute bronchitis, in pediatric hospitalizations, which were often unrecognized. 1,2In Tunisia, according to previous data, the prevalence of asthma was estimated to be around 4.3% in 2008 in children, in second place after the elderly. 3 Bronchiolitis hospitalizations have increased considerably since 1980, resulting in a problem for public health in Tunisia and the whole world. 4 This alarming situation prompted authorities and health-care managers to plan preventive actions as soon as possible. Climate factors and environmental change play a major role in the epidemiology of pulmonary infectious diseases, resulting in significant seasonal variations in terms of prevalence.5 Better knowledge of the new epidemiological profile will help decision makers to ...

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