The aim of this paper is to report a clinical case of a male patient with Peters-plus syndrome. This syndrome is a rare, autosomal recessive congenital disorder. It is diagnosed by the presence of ocular changes associated with delayed psychomotor development, cardiac defects, and characteristic facial features, such as cleft lip, hypertelorism, narrow eyes, prominent forehead, and hearing loss. Clinical examination revealed gingival hyperplasia in the upper and lower arches resulting from the use of phenobarbital, associated with the presence of a large amount of dental biofilm, and active white spot lesions in the upper deciduous incisors. Replacement of the anticonvulsant medication was requested. Guidelines on oral and dietary hygiene habits as well as topical application of fluoride varnish were provided. Hyperplasia was reversed in 2 weeks and the patient has been receiving follow-up care. The patient is being monitored and his oral condition has improved. (Rev Port Estomatol Med
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