Significant HRV reduction is a precursor to incipient heart failure (NYHA I). In heart failure progression, total power as well as the power of all spectral components is progressively reduced. LF and Tot Power are the most prominent parameters for discriminating between the different stages of heart failure. These results could promote HRV as an important decision-making tool in heart failure treatment as well as in monitoring the results of that treatment.
These data suggest that SDB increases HRV both in healthy and heart failure patients; the highest increment is in LF range. Differences in spectral profile of HRV between healthy controls and heart failure patients become more profound during SDB. Controlled respiration during HRV analysis might increase sensitivity and reliability in detection of autonomic dysfunction in heart failure patients.
Serotonin syndrome is a potentially severe acute adverse reaction to a serotonin agonist. It is characterized by cognitive and behavioral changes, autonomic dysfunction and neuromuscular abnormalities. The growing use of SSRIs is related to the frequency of the syndrome. The aim of our presentation was to describe a unique case of severe hyperserotoninergic state caused by a single dose of fluvoxamine and an analgesic drug. Physicians who prescribe SSRIs should be aware that the patient is not a medical specialist and needs detailed information on any new drug he has been prescribed.
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