Dermatomyositis (DM) is a rare autoimmune disease characterized by symmetric proximal muscle weakness and skin rashes. Corticosteroids and methotrexate are mainly prescribed to treat dermatomyositis based on the consensus of experts. Intravenous immunoglobulin is used in severe cases to reduce the dose and duration of corticosteroid therapy, the number of flare-up periods, thereby reducing complications and sequelae. Subcutaneous immunoglobulin has advantages over intravenous immunoglobulin because it can be used at home and maintains stable blood gammaglobulin levels. We report a case of a 2-years old child with early-onset dermatomyositis treated with subcutaneous immunoglobulin. The child’s condition improved, and corticosteroids were discontinued after 18 months of treatment. We prove that subcutaneous immunoglobulin therapy can shorten the duration of corticosteroid therapy in children with dermatomyositis.
Objective: The Pediatric Sleep Questionnaire (PSQ) has shown to be a valuable screening tool with good sensitivity and specificity for obstructive sleep apnea among children. Our aim was to cross-culturally translate and adapt the PSQ into Vietnamese language for clinical and research using. Methods: The Vietnamese version of the SRBD-PSQ was translated by the University of Michigan, which reserves the copyrights. The adapted questionnaire was applied to parents of 60 children aged 6 - 14 years. The reliability of the translated questionnaire was measured by Cronbach α, Pearson correlation and Kappa statistics. Results: Vietnamese PSQ has shown high internal consistency by Cronbach’s α (0.781 for the total test, 0.745 for subscale “snoring”, 0.682 for “sleepiness”, 0.763 for “behaviour”). Test-retest reliability for all items presented a good correlation, with the Kappa statistic ranged between 0.498 and 0.832. Conclusion: The Vietnamese version of PSQ has sufficient reliability and validity to measure obstructive sleep apnea outcome and showed to be linguistically accurate and acceptable for use among Vietnamese children.
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