Background: Polyphenolic compounds have anti-proliferative effects and can trigger apoptosis in cancer cells. Ferulic acid is excessively found in various herbal products and fruits. Ferulic acid plays a role in the treatment of neurodegenerative diseases, cancer, diabetes, cardiovascular disease, inflammation, and bacterial and viral infections. Objectives: The purpose of this study was to evaluate the anticancer effect of ferulic acid on renal carcinoma cells (ACHN). Methods: To assess the anti-proliferative effect of ferulic acid, the renal carcinoma cell line (ACHN) was treated with different ferulic acid concentrations (10, 20, 40, 80, and 160 μM) for 24, 48, and 72 hours. Cell viability was measured using the MTT assay. The apoptosis of cancer cells was evaluated by flow cytometry and real-time PCR. Results: The IC50 of ferulic acid against ACHN cells was determined to be 30 μM at 72 hours with the MTT assay. The treatment of cells with ferulic acid concentrations of 30 and 60 μM caused a significant increase in the apoptosis index. The Bcl-2 gene expression level was significantly lower in the treated group than in the control group, and the Bax gene expression level was significantly higher in the treated group than in the control group (P < 0.001). Conclusions: The results of this study showed the apoptotic activity of ferulic acid against ACHN cells. These results can be helpful in the better understanding of the anticancer mechanism of ferulic acid, suggesting this substance as an alternative drug or in combination with conventional chemical treatments for cancer treatment.
Background: Identification of human errors and their related factors in nurses dealing with the health of humans is important. Considering that much workload can increase the risk of human error, this study aimed to investigate the relationship between workload and human errors among nurses working in educational hospitals of Kerman University of Medical Sciences. Methods: This descriptive-analytical study was performed on 145 nurses from educational hospitals affiliated to Kerman University of Medical Sciences in 20. The workload was evaluated using the NASA-TLX questionnaire and human errors with SHERPA technique. The statistical test used was logistic regression model and the statistical significance level was considered <0.05 and the samples were selected randomly. The sample size was selected based on the percentage of functional errors reported by a study on human error assessment related to the duties of nurses in Semnan. Results: A total of 138 probable errors were detected in the nursing staff of these hospitals, 74% of nurses committed errors in seven main duties during their service. Patient medication with the highest frequency (34%) followed by the injection of the drug to the patient with a frequency of 23% were the most frequently committed errors by nurses. The findings of the research showed that workload in 53.1% of the nurses was very high and in 43.1% of the nurses was high, the results of the logistic regression model showed that there was no significant relationship between errors and workload in nurses. Conclusion: The results of the study showed that the average workload and human error in the nurses were high. Therefore, control strategies such as holding training sessions, implementation of clinical governance program in all wards, recruitment of adequate nurses, reduction of workload, reduction of work hours and the appropriate patient/nurse ratio should be given attention by the hospital managers depending on conditions; as well as the prevention of the two reported errors should be given top priority in corrective measures.
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