Introduction: American Diabetes Association updates its guideline every year. However this guideline can be changed for different populations based on their cultural and genetic status.
Objectives: We intend to design a regional study in Lur and Lak populations of Iran using receiver operating characteristics (ROC) curve model.
Patients and Methods: A total of 133 diabetes mellitus (DM) patients were enrolled in this study. The collected information for each patient were gender, age, body mass index (BMI), DM type, DM duration, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile, type of treatments, type of statin and dose, documented neuropathy, documented nephropathy, symptomatic retinopathy, peripheral vessel disease (PVD), documented cardiovascular disease (CVD), food ulcer history, dawn effect, systolic blood pressure (SBP), and diastolic blood pressure (DBP). ROC curve was used and area under curve (AUC) was reported.
Results: For neuropathy, age was the most accurate diagnostic index (area under curve [AUC] = 79%). For nephropathy SBP was the most accurate diagnostic index (AUC= 88%). For symptomatic retinopathy DM duration was the most accurate diagnostic index (AUC= 81%). For PVD, HDL-C was the most accurate diagnostic index (reverse AUC= 67%). For CVD age was the most accurate diagnostic index (AUC= 81%). For foot ulcer history age was the most accurate diagnostic index (AUC= 85%). Conclusion: The final suggested guideline is like the international guidelines. However some unique points should be regarded. Blood pressure >165/110 mm Hg is diagnostic of diabetic nephropathy. Additionally serum high-density lipoprotein (HDL-C) >48 mg/dL is strongly suggested.
Introduction: latent tuberculosis infections (LTBI) are not detectable by a single-stage tuberculin test and maybe detected after repeating tests 7-21 days later. This phenomenon, called the boosting phenomenon, supports a two-stage test to identify false negatives in a single-stage test. The present study investigates the value of a two-stage tuberculin test in diabetic patients. Methods: We performed a tuberculin test for 195 diabetic patients. The patients with induration > 10 mm were subjected to a second tuberculin test 7-21 days later. Results: Of 195 patients, 115 came for measuring the tuberculin test induration, which was positive in 3 out of 115 patients (2.61%). Of the remaining 112 patients, 53 patients were subjected to the second test, and 38 patients came back for measuring the induration, which became positive in 4 (10.52%) patients. Conclusion: The increased LTBI rate from 2.61% to 10.52% following the second tuberculin test indicates a boosting phenomenon due to a delayed hypersensitivity reaction. Hence, patients with latent tuberculosis who had a false negative test in the first stage were identified.
Introduction: Tuberculosis is the leading cause of death from infectious diseases worldwide. Diabetes has been suggested as an important risk factor for tuberculosis. To date, few studies have examined the association between diabetes and tuberculosis. In this study, the prevalence of latent tuberculosis in diabetic patients was investigated.
Methods: In this study, 195 patients with type 2 diabetes were studied in a cross-sectional study to diagnose latent tuberculosis infection with a tuberculin skin test. Individuals with symptoms of active tuberculosis were excluded from the study, and individuals with a positive tuberculin test were evaluated for active tuberculosis by chest x-ray. For analyzing the data, SPSS software version 16 was run, a t-test was used to analyze quantitative variables, and for qualitative variables, Chi-square was applied. The significance level of 0.05 was considered for all the results.
Results: Out of 195 diabetic patients, 115 patients were referred for tuberculin test results. 43 out of 115 patients (37.39%) had an induration diameter greater than or equal to 5 mm, 29 patients (25.21%) had an induration diameter greater than or equal to 8 mm, and 3 patients (2.61%) had an induration diameter greater than or equal to 10 mm (Positive tuberculin test) (p>0.05).
Conclusion: False tuberculin skin test results can hide the true prevalence of latent tuberculosis infection. The sensitivity of the tuberculin test decreases in immunocompromised patients and leads to limitations in assessing the prevalence of latent tuberculosis infection. Although not enough information was available in this study to establish a significant association between diabetes and latent tuberculosis infection, further studies will help to investigate this association.
Background Reactive oxygen species cause serious damage to the physiological function of tissues. Determination of total antioxidant capacity of skin tissue is one of the determinants of damaged tissue function. Mast cells (MCs) are one of the groups of cells that are invited to the site of injury. The healing process begins with the rapid release of various types of MCs' intermediate factors at the site of injury. Bone marrow mesenchymal stem cell (BMMSC) production and secretion have been shown to regenerate the skin. The aim of this research was to evaluate the wound-healing and antioxidant effects of BMMSCs per MCs.
Methods Fifty-four albino Wistar male rats were divided into three groups: (1) nonsurgery, (2) surgery, and (3) surgery + BMMSCs. Groups 2 and 3 were operated with a 3 × 8 cm flap and in group 3, cell injections (7 × 109 cell injection at the time of surgery) were performed. After days 4, 7, and 15, percentage of the surviving tissue, histological characteristics, superoxide dismutase (SOD) activity, and amount of malondialdehyde (MDA) were measured in the groups. For results, Graph Pad Prism 8 software was used, and data were analyzed and compared by analysis of variance and Tukey test.
Results BMMSCs' application decreased the amount of MDA, increased SOD activity and survival rate of the flaps, and improved the histological characteristics.
Conclusion This study revealed the protective effects BMMSCs alongside MCs against oxidative stress on the survival of the flaps. However, for clinical use, more research is needed to determine its benefits.
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