A novel magnetic heterogeneous catalyst was synthesized through the immobilization of copper ions onto the l-arginine functionalized CuFe2O4@SiO2. The prepared catalyst was characterized by Fourier Transform Infrared (FT-IR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), and Energy Dispersive X-Ray spectroscopy (EDX). The resulting catalyst was used in the ultrasonic-assisted synthesis of 1,2,3-triazoles via a one-pot three-component reaction of alkynes, alkyl halides, and sodium azides under green conditions within a short time. The catalyst reusability was investigated after five cycles and no significant loss of activity was observed.
A novel magnetic heterogeneous catalyst was synthesized through the immobilization of copper ions onto the l-arginine functionalized CuFe2O4@SiO2. The prepared catalyst was characterized by Fourier Transform Infrared (FT-IR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), and Energy Dispersive X-Ray spectroscopy (EDX). The resulting catalyst was used in the ultrasonic-assisted synthesis of 1,2,3-triazoles via a one-pot three-component reaction of alkynes, alkyl halides, and sodium azides under green conditions within a short time. The catalyst reusability was investigated after five cycles and no significant loss of activity was observed.
Collagen-based hydrogels as scaffolds are one of the most widespread biological materials used in biomedicine and drug carriers. The aim of the current study was to develop a vitamin E (VE) loaded hydrogel films based on fish scale collagen (FSC) and carboxymethyl cellulose crosslinked with triethanolamine (TEA) to evaluate their Vitamin E release efficiency, antibacterial and antioxidant properties. The effect of different collagen content on film properties was investigated. The physical and morphological properties of the extracted FSC and the films were determined different analytical technics. The in-vitro properties of the films, the loading and releasing of VE showed that the highest amount of VE loading (98.1%) and release (92.3%) was achieved for the 14.1 wt% collagen film. The antibacterial assay of the prepared film against E. coli and S. aureus indicated a 2log reduction after 24 h, corresponding to 99% percent reduction. Based on DPPH radical scavenging activity, FSC/CMC/TEA/VE film showed scavenging activity when compared with standard Vitamin C and FSC/CMC/TEA. Moreover, according to the results of MTT test, the film has no toxic effect. Based on these results, the prepared hydrogel film seems to be a promising option in the field of drug delivery.
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