Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water‐soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan‐based delivery of curcumin.
The aim of this study was to synthesize nickel oxide nanoparticle (NiO-NPs) by Rheum turkestanicum (RT) root extract, which is a local medicinal plant. The synthesized NiO-NPs have been characterized by field emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) methods. We have evaluated the cytotoxicity of NiO-NPs on the WEHI 164 murine fibrosarcoma cells by MTT assay. The photocatalytic properties of NiO-NPs was investigated by observing the removal of Rhodamine-B (RB) in aqueous media. It has been displayed by the obtained results that NiO-NPs have been synthesized in a Hexagonal (Rhombohedral) lattice system with the size of about 12-15 nm. According to the results, almost 95% of RB has apparently degraded in the presence of NiO-NPs under UV-light after 30 h. It has been illustrated by the cytotoxicity effects against the WEHI 164 murine fibrosarcoma cells that 250 μg/ml of NiO-NPs is capable of eliminating about 70% of these tumors' cells. The IC 50 of the NiO-NPs has been calculated to be 25 μg/ml. The introduced green method can replace the available chemical procedures, which involve using hazardous substances that are a threat to the human health.[a] M. Saheb
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.