A two-component condensation reaction between an imide and an electronpoor acetylenic ester efficiently provides substituted electron-poor N-vinyl imides in a one-pot reaction in the presence of dipotassium hydrogen phosphate powder in solventfree conditions. The reaction is fairly stereoselective.
Nowadays, a great sustainable and economic development to introduce efficient and easy magnetically recoverable and reusable gold catalysts for A 3 -coupling reaction in water, it is still pursued. In this work, a new heterogeneous catalyst, comprising gold supported on DABCO-Triazole modified magnetic nanoparticles (Fe3O4@DT-Au), is developed for A 3coupling reaction. This catalyst is characterized using different techniques such as TEM, SEM, SEM-elemental mapping, XRD, XPS, and TGA. Using a 0.05 mol% of this catalyst, the three-component reaction of amines, aldehydes and alkynes is efficiently perfomed at 40 °C in neat water. This catalyst is easily recovered and recycled for six times with a small decrease in the activity.
Yields in the microwave-promoted reaction are slightly higher than those obtained by classical thermal heating. The reaction is fairly stereoselective. -(RAMAZANI*, A.; KARDAN, M.; NOSHIRANZADEH, N.; Synth. Commun. 38 (2008) 3, 383-390; Dep. Chem., Univ. Zanjan, Zanjan, Iran; Eng.) -H. Haber
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