Enantiomerically pure chiral amines are valuable synthetic intermediates, particularly for the preparation of pharmaceutical compounds. Traditionally, chiral amines have been obtained by resolution-based procedures, for example, by kinetic resolution of a racemate using an enzyme [1,2] or crystallization of a diastereomer using a chiral acid to form a salt. [3] Increasingly, there is a desire to develop asymmetric approaches, or their equivalents, which can in principal deliver the product in 100 % yield and 100 % ee. For example, transaminases have been utilized for the conversion of COMMUNICATIONS

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Enantiomerically pure chiral amines are valuable synthetic intermediates, particularly for the preparation of pharmaceutical compounds. Traditionally, chiral amines have been obtained by resolution-based procedures, for example, by kinetic resolution of a racemate using an enzyme [1,2] or crystallization of a diastereomer using a chiral acid to form a salt. [3] Increasingly, there is a desire to develop asymmetric approaches, or their equivalents, which can in principal deliver the product in 100 % yield and 100 % ee. For example, transaminases have been utilized for the conversion of ZUSCHRIFTEN

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