Introduction: Surgical extraction of impacted third molars has become a routine procedure in most of dental clinics. Tissue adhesives based on Nbutyl cyanoacrylate are employed as a non-suture method for intra-oral postsurgical wound closure. Objectives: Evaluation of the clinical post-operative complications after the use of N-butyl cyanoacrylate soft tissue adhesive in closure of mucoperiosteal flaps after the surgical extraction of impacted mandibular third molars compared to the use of conventional silk sutures. Materials and methods: This study was conducted on twenty patients of both sexes ranging from 20 to 30 years of age.Patients were divided equally into two groups (Study and control groups) each with mesioangular impacted mandibular third molar (class II position B according to Pell and Gregory's classification). After the surgical extraction of impacted teeth the flaps were closed using PeriAcryl 90 (Glustitch corporation, Delta, BC, Canada) soft tissue adhesive in the study group and using 3/0 silk sutures in the control group. Patients were evaluated for pain, bleeding, trismus, facial swelling, wound dehiscence and local reaction. Results: There was a statistically significant reduction of pain, bleeding, trismus, wound reaction on using the N-butyl cyanoacrylate (PeriAcryl 90) compared to sutures , concerning wound dehiscence and facial swelling , the results of both materials were nearly the same. Conclusion: The use of the N-butyl cyanoacrylate (PeriAcryl 90) for the closure of mucoperiosteal flaps is a reliable method that can overcome most of complications faced on using conventional silk sutures in addition to ease of manipulation , time saving and safety factors.