Alzheimer’s disease (AD) consists of the gradual process of decreasing volume and quality of neuron connection in the brain, which consists of gradual synaptic integrity and loss of cognitive functions. In recent years, there has been significant attention in AD classification and early detection with machine learning algorithms. There are different neuroimaging techniques for capturing data and using it for the classification task. Input data as images will help machine learning models to detect different biomarkers for AD classification. This marker has a more critical role for AD detection than other diseases because beta-amyloid can extract complex structures with some metal ions. Most researchers have focused on using 3D and 4D convolutional neural networks for AD classification due to reasonable amounts of data. Also, combination neuroimaging techniques like functional magnetic resonance imaging and positron emission tomography for AD detection have recently gathered much attention. However, gathering a combination of data can be expensive, complex, and tedious. For time consumption reasons, most patients prefer to throw one of the neuroimaging techniques. So, in this review article, we have surveyed different research studies with various neuroimaging techniques and ML methods to see the effect of using combined data as input. The result has shown that the use of the combination method would increase the accuracy of AD detection. Also, according to the sensitivity metrics from different machine learning methods, MRI and fMRI showed promising results.
This study will concentrate on recent research on EEG signals for Alzheimer’s diagnosis, identifying and comparing key steps of EEG-based Alzheimer’s disease (AD) detection, such as EEG signal acquisition, preprocessing function extraction, and classification methods. Furthermore, highlighting general approaches, variations, and agreement in the use of EEG identified shortcomings and guidelines for multiple experimental stages ranging from demographic characteristics to outcomes monitoring for future research. Two main targets have been defined based on the article’s purpose: (1) discriminative (or detection), i.e., look for differences in EEG-based features across groups, such as MCI, moderate Alzheimer’s disease, extreme Alzheimer’s disease, other forms of dementia, and stable normal elderly controls; and (2) progression determination, i.e., look for correlations between EEG-based features and clinical markers linked to MCI-to-AD conversion and Alzheimer’s disease intensity progression. Limitations mentioned in the reviewed papers were also gathered and explored in this study, with the goal of gaining a better understanding of the problems that need to be addressed in order to advance the use of EEG in Alzheimer’s disease science.
There is a wide variety of effects of Alzheimer’s disease (AD), a neurodegenerative disease that can lead to cognitive decline, deterioration of daily life, and behavioral and psychological changes. A polymorphism of the ApoE gene ε 4 is considered a genetic risk factor for Alzheimer’s disease. The purpose of this paper is to demonstrate that single-nucleotide polymorphic markers (SNPs) have a causal relationship with quantitative PET imaging traits. Additionally, the classification of AD is based on the frequency of brain tissue variations in PET images using a combination of k-nearest-neighbor (KNN), support vector machine (SVM), linear discrimination analysis (LDA), and convolutional neural network (CNN) techniques. According to the results, the suggested SNPs appear to be associated with quantitative traits more strongly than the SNPs in the ApoE genes. Regarding the classification result, the highest accuracy is obtained by the CNN with 91.1%. These results indicate that the KNN and CNN methods are beneficial in diagnosing AD. Nevertheless, the LDA and SVM are demonstrated with a lower level of accuracy.
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