Background: Mullerian anomalies are relatively common and contributing to the problems of infertility and poor pregnancy outcomes. But their molecular pathophysiology has been insufficiently studied. On the other hand, polycystic ovary syndrome (PCOS) is found in nearly 80% of women with hyperandrogenism and also in 8% -25% of normal ones. It seems that anti-mullerian hormone (AMH) which inhibits the formation of the mullerian ducts in male increases in women with PCOS. Therefore, the aim of the study is whether PCOS is associated with mullerian anomalies. Methods: In this case-control study, 83 women with PCOS and 83 cases without PCOS were evaluated with transvaginal ultrasound (TVS) for the diagnosis of mullerian anomalies. The results of each group were compared with other groups. Results: In the PCOS patients, TVS revealed mullerian anomalies in the uterine cavity in 29 out of 83 women. Among 29 patients who had lesions in their uterine cavity, 27 cases had septate uterus and two had arcuate uterus. In the healthy women, TVS revealed 6 septate uterus and 4 arcuate uterus abnormality cases of the uterine cavity. There were significant correlation between polycystic ovary syndrome of the patients and the mullerian anomalies lesions (i.e. septate and arcuate uterus) which were seen in them. Conclusion: Mullerian anomalies were more common in women with PCOS and the most common anomaly was uterine septum. In fact, the present results revealed that it seemed a cause-effect relationship between the mullerian anomalies and PCO syndrome may in fact exist.
Virtual poster abstracts Objectives: Maternal hemodynamics, in particular cardiac output (CO), are assuming importance in the management and investigation of women with fetal growth restriction (FGR) and pre-eclampsia (PET). However, there are many different techniques. We compared two different methods (gas rebreathing and bio-impedance) in this study of maternal hemodynamics during study of women undergoing in vitro fertilisation (IVF) treatment. Methods: This was an observational, prospective longitudinal study. 74 women were recruited from those registered to commence IVF treatment at The Wolfson Fertility Centre, Hammersmith Hospital, between August 2018 and December 2019. Inclusion criteria were women aged 18-44yrs, with no pre-existing cardiac morbidity or any chronic conditions who were having either a fresh or frozen IVF cycle. Four time points during IVF treatment were selected to measure CO. The Innocor ® , is an inert gas re-breathing device and the NICaS ® uses whole body bio-impedance as a method of measuring CO. Neither have been validated in women undergoing IVF. CO measurements taken from both devices at the single time points were compared using the Bland-Altman analysis. Longitudinal changes in CO using both devices were compared using a 4-quadrant plot. Results: A total of 113 measurements of CO from 44 recruits were suitable for Bland-Altman analysis. The mean CO for Innocor ® was 4.6L/min and for NICaS ® was 5.05L/min. The bias was 0.44 L/min, with a percentage error of 76% and the intraclass correlation coefficient (ICC) was 0.135 (95%CI-0.43 to 0.306). 61 measurements of CO from 28 participants were suitable for longitudinal analysis of the comparability of the two devices using a 4-quadrant plot. Longitudinal concordance was found to 59%. Conclusions: These outcomes do not support the interchangeable use of the NICaS ® and Innocor ® when measuring CO. Though this study was peformed in women undergoing IVF, its results are likely to be generalisable in women undergoing pregnancy. VP64.16 Effect of two-dimensional ultrasound and colour Doppler of endometrium on pregnancy outcome in IUI cycle
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