The study was aimed to evaluate the performance of a newly developed spectroscopy-based non-invasive and noncontact device (SAMIRA) for the simultaneous measurement of hemoglobin, bilirubin and oxygen saturation as an alternative to the invasive biochemical method of blood sampling. The accuracy of the device was assessed in 4318 neonates having incidences of either anemia, jaundice, or hypoxia. Transcutaneous bilirubin, hemoglobin and blood saturation values were obtained by the newly developed instrument which was corroborated with the biochemical blood tests by expert clinicians. The instrument is trained using Artificial Neural Network Analysis to increase the acceptability of the data. The artificial intelligence incorporated within the instrument determines the disease condition of the neonate. The Pearson’s correlation coefficient, r was found to be 0.987 for hemoglobin estimation and 0.988 for bilirubin and blood gas saturation respectively. The bias and the limits of agreement for the measurement of all the three parameters were within the clinically acceptance limit.
The current COVID-19 pandemic has increased the use of facial masks globally, which of late have registered their presence as a part of our civilization. The N95 mask is one of the most popular choices under the current situation. However, the available masks cannot provide breathing comfort for an extended period, which results in rebreathing of exhaled air that is CO2 rich, and which remains in the breathing space of the respirator. Furthermore, problems like moisture settlement on the covered area of the face due to the multiple layers of fabric-like material causes significant discomfort. Hence, the need for a mask with an air-purification activity is the need of the hour. The present innovation relates to the invention of a mask that is battery-powered or solar-operated and addresses the aforementioned problems. This mask not only regulates the airflow, which is beneficial to our body in every way, but also lowers the discomfort of sweating and heating. The effect of the addition of the self-developed active respirator to the commercially available masks on the inspired CO2 level, thermal comfort, and speech clarity has been demonstrated in this study. We have exhibited through in vitro experiments that the filtration capability of the active-respirator improvised mask, we call the Bose shield, does not deter from that of the standard N95 mask. To our understanding, the use of this novel mask can reduce the occurrence of CO2 rebreathing in respiratory protective devices and its impact on workers who inevitably wear them for a prolonged period of time.
Sorafenib is an anticancer drug is used to treat late stage kidney and liver cancer. Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine. Sorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. There are many reported analytical methods for estimation of Sorafenib. The present work list outs the various analytical methods for the estimation of the drug.
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