The ethanol extract of Stereospermum suaveolens (EESS) bark was evaluated for its antihyperglycemic in addition to antioxidant effects in streptozotocin (STZ)-induced diabetic rats by acute and subacute models at dose levels of 200 and 400 mg/kg body weight, given orally. The ethanol extract showed a significant reduction in fasting blood glucose levels when compared to the standard drug, oral Glibenclamide (0.5 mg/kg body weight). The serum of rats treated with ethanol extract showed decreased levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, bilirubin, creatinine, urea, total cholesterol, triglycerides, and increased level of total proteins. EESS showed reduction in thiobarbituric acid reactive substances level and significantly increased the body weight (P < .001), glycogen, reduced glutathione, superoxide dismutase, and catalase activities, compared with STZ diabetic control in a dose-dependent manner. This finding shows that the ethanol extract of Stereospermum suaveolens exhibits potent antihyperglycemic and antioxidant properties.
In1981, Dr. A.I.G.Brain 1 designed the prototype of LMA. It is an excellent device to maintain airway in selected surgeries and obviates the need for endotracheal intubation. In year 1996, LMA was incorporated in ASA difficult airway algorithm. 2 Other advantages of LMA, like smoother transition from anaesthesia to emergence with LMA in situ and requirement of lesser skill for ABSTRACT Background: Laryngeal mask airway has already gained widespread acceptance as an alternative airway device and conduit for endotracheal intubation. Insertion of this Supraglottic Airway Device (SAD) to provide and maintain a seal around the laryngeal inlet for spontaneous ventilation as well as modest level of positive pressure ventilation requires a sufficient depth of anaesthesia and depression of airway reflexes to avoid adverse reactions like gagging, coughing, head and limb movements etc. This study was conducted with the intent to compare Vital Capacity Breath (VCB) inhalation with 8% sevoflurane versus intravenous (IV) propofol for quality and ease of insertion of Laryngeal Mask Airway (LMA) and associated complications Methods: In this prospective, randomized study, 80 adult patients of ASA physical status I and II aged between 20 to 50 years, body weight <70 kg scheduled for short operative procedures under general anaesthesia were selected. The patients were divided into two groups. GroupS (n=40) were induced with 8% sevoflurane with 67% nitrous oxide in oxygen with a total gas flow of 8 litres per minute and group-P (n=40) were induced with injection propofol 2.5 mg/kg body weight intravenously. Results: Insertion of LMA at first attempt was 92.5% with sevoflurane (VCB) and 95% with propofol. Time to loss of consciousness was 35.98 ± 6.23s and 36.26 ± 5.65s in group S and group P respectively. Complications were similar in both the groups. Conclusions: A vital capacity induction with sevoflurane shows a slight faster loss of consciousness. The time to successful LMA insertion at 1 st attempt and the incidence of side effects were similar in both the group (P >0.05).
The present study was designed to evaluate the in vivo anticancer activity of methanolic and aqueous extract of Leucas indica Linn. (Aerial parts) against Ehrlich’s Ascites Carcinoma (EAC) on Swiss albino mice. The anticancer activity was done by intra peritoneal transplantation of EAC cells into mice and subsequently analysis of ascitic fluid, haematological, biochemical and histopathological parameters along with body weight and percentage of life span. The animals were treated with the extracts at the dose level of 200 and 400 mg/kg, intra peritoneally and compared to the reference drug vinblastine. Both the extracts showed significant dose dependent reduction of viable cells (cancer cells), increased non-viable cells (dead cells), decreased in body weight and increased the duration of life span. In case of hematological study the extracts showed increased hemoglobin level and RBC count but decreased WBC count. The certain important serum enzymes like glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and alkaline phosphatase levels were also decreased in treated group of animals. Finally, in case of histopathological investigation of livers showed a significant protection and regeneration of EAC induced oxidative stress and cellular damage. The preliminary phytochemical screening of the extracts revealed the presence of flavonoids, total phenolic compounds, saponin and tannin. However the aqueous fraction of the Leucas indica possesses more potential anticancer property compared to methanolic fraction. The anticancer property of this plant was considered due to the presence of flavonoids and total phenolic compounds
Methanolic extract of tea leaves (Camellia sinensis Linn.) of autumn and rain collections (SA and SR respectively) were investigated for in vitro antioxidants, antibacterial and wound healing activities to correlate with the impact of seasonal variation on phytoconstitutional content and commercial disparity. Both the extracts were subjected for quantitative and qualitative analysis and different concentrations (SA100, SA200, SR100 and SR200) were investigated for in vitro antioxidant activity performing DPPH, super oxide anion, hydrogen peroxide, hydroxyl radical scavenging assay and measurement of reductive ability. The antibacterial activity of SA and SR was evaluated against eight human pathogens (two Gram positive and six Gram negative) using disc diffusion method and minimum inhibitory concentration of each was determined. The influence of SA and SR in 250 and 500 mg/Kg body wt. on rate of wound closure were investigated using the excision wound model on female wister rats (Sprague Dawley) and histological investigations of treated and untreated wound tissues were performed to observe epithelialisation, fibroblast proliferation, neovascularisation, neutrophil infiltration, and collagen deposition. The SR extract showed higher antioxidant activities compared to SA. Both the extracts showed significant antibacterial activities. The topical administration of SR500 caused significantly faster healing (99.05%), more epithelialisation, less neutrophils infiltration, higher deposition of collagen and better angiogenesis in wound area as compared to the SA500 and standard. These results limpidly showed that the SR extract possess superior wound healing properties due to its higher anti oxidant and better microbial spectrum coverage probably by containing sesquiterpene derivative and higher flavonoid analogues.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.