The most favored approach for drug administration is the oral route. Several anticancer drugs come under this category and mostly lack solubility and oral bioavailability, which are the most common causes of inadequate clinical efficiency. Enhancing oral absorption of anticancer drugs with low aqueous solubility and drug impermeability is currently an effective area of research. Many scientists have looked into pharmaceutical cocrystals as a way to improve the physicochemical properties of several anticancer drugs. Benefits of pharmaceutical cocrystals over other solid forms may include improved solubility, bioavailability, and a reduced susceptibility for phase transition. Cocrystal strategy also stands as a green synthesis tool by using very limited organic solvents during its formulation. Having so many advantages, to date, the reported cocrystals and drug–drug cocrystals of anticancer drugs are limited. Here we review the pharmaceutical cocrystals and drug–drug cocrystals of the anticancer drugs reported in the last decade and their future in imaging, and also shed light on the opportunities and challenges for the development of anticancer drug cocrystals.
Background: The combination of antibiotics with an immune-stimulant can be used for the prevention of antimicrobial resistance. Multilayer tablets of linezolid and levamisole hydrochloride can be a solution of this problem. Objective: Aim of the present study was to High Performance Liquid Chromatography method development and validation as per the International Council for Harmonisation guidelines for analysis of both the drugs simultaneously in a single unit dosage form. Methods: Ammonium acetate and acetonitrile in the ratio 65:35 (%v/v) was used as mobile phase. Ultra violet detection was carried out at 236 nm and flow rate was kept as 0.9 mL/min. Results: Linezolid and levamisole hydrochloride were found at 4.61 min and 6.45 min retention times, respectively. Conclusion: The study confirmed that the present method can be used for routine simultaneous analysis of linezolid and levamisole hydrochloride.
Drug delivery systems made based on nanotechnology represent a novel drug carrier system that can change the face of therapeutics and diagnosis. Among all the available nanoforms polymersomes have wider applications due to their unique characteristic features like drug loading carriers for both hydrophilic and hydrophobic drugs, excellent biocompatibility, biodegradability, longer shelf life in the bloodstream and ease of surface modification by ligands. Polymersomes are defined as the artificial vesicles which are enclosed in a central aqueous cavity which are composed of self-assembly with a block of amphiphilic copolymer. Various techniques like film rehydration, direct hydration, nanoprecipitation, double emulsion technique and microfluidic technique are mostly used in formulating polymersomes employing different polymers like PEO-b-PLA, poly (fumaric/sebacic acid), poly(N-isopropylacrylamide) (PNIPAM), poly (dimethylsiloxane) (PDMS), and poly(butadiene)(PBD), PTMC-b-PGA (poly (dimethyl aminoethyl methacrylate)-b-poly(l-glutamic acid)) etc. Polymersomes have been extensively considered for the conveyance of therapeutic agents for diagnosis, targeting, treatment of cancer, diabetes etc. This review focuses on a comprehensive description of polymersomes with suitable case studies under the following headings: chemical structure, polymers used in the formulation, formulation methods, characterization methods and their application in the therapeutic, and medicinal filed.
Objective: The aim of the present study was to prepare a pantoprazole rosin complex tablet which would stabilize the drug in the mild acidic condition (pH 5) of the stomach during the fed state.
Methods:The method of slow solvent evaporation and antisolvent was used for the preparation of pantoprazole rosin complex.
Results:The prepared pantoprazole rosin complex exhibited decreased solubility than that of pure drug. Fourier transform infrared spectroscopy and differential scanning calorimetry studies confirmed the formation of a complex between the pantoprazole sodium and rosin through weak ionic bonds. The in vitro release studies of the pantoprazole rosin complex showed more than 80% release at the end of 90 minutes. Tablets were formulated using direct compression method and the prepared tablets were evaluated in vitro. The tablets were found to be within official limits with respect to hardness, weight variation, drug content, friability, etc.
Conclusion:The tablet formulated with croscarmellose sodium as superdisintegrant showed 97% drug release within 60 minutes. The optimized tablets were found to be stable in accelerated study conditions for 1 month with respect to physical characteristics and drug content. If this process can be scaled up to manufacturing level, this technique has the potential to develop into an invaluable technology in future.
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