Background: Several treatment options are available for restorative dental treatment of moderate to large teeth defects. However, in recent years, improved computer-aided design and computer-aided manufacturing (CAD/CAM) technology show several advantages, including favorable esthetic results, conservative preparation techniques and cost-effectiveness hence the aim of the study was to search for the best available evidence in investigating whether CAD/CAM fabricated partial coverage restorations will show better marginal adaptation and provide an evidence-based clinically relevant statement. Methodology: An extensive search was performed using four online databases. Search strategies were developed for each online database, the studies were reviewed by three independent authors, and inclusion/exclusion criteria were applied and the quality of the included studies was assessed. Results: The initial search resulted in 998 studies from all the databases. Six clinical studies were identified as relevant to the research question and were included in the qualitative assessment. Conclusions: Marginal adaptation of CAD/CAM-fabricated restoration shows excellent clinical outcomes in short-term observation periods. There is a need for clinical trials that compare the clinical outcomes of CAD/CAM-fabricated restoration to direct composite restorations.
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