The clinical efficacy of topical administration of standardised fermented papaya gel (SFPG), known to have antioxidant and anti-inflammatory properties, versus conventional therapy was evaluated in a group of 84 patients with moderate-to-severe periodontitis, randomly assigned to control group (n = 45) undergoing traditional pharmacologic/surgical protocols or to experimental group (n = 39), additionally treated with intragingival pocket SFPG (7 g) applications (15 min daily for 10 days). Patients undergoing SFPG treatment showed significant (P < 0.05), durable improvement of three major clinical indices of disease severity: reduced bleeding (day 7), plaque and gingival conditions (day 14), and consistent gingival pocket depth reduction (day 45). Proinflammatory nitric oxide metabolites reached normal values in plasma (day 14) and gingival crevicular fluid (GCF) at day 45 with SFPG applications compared to controls that did not reach normalisation. Levels of highly increased proinflammatory (IL-1B, IL-6) and suppressed anti-inflammatory (IL-10) cytokines normalised in the SFPG group by days 14 (plasma) and 45 (GCF), but never in the control group. Although not acting directly as antibiotic, SFPG acted in synergy with human granulocytes blocking adaptive catalase induction in S. aureus in response to granulocyte-derived oxidative stress, thus enhancing intracellular bacterial killing.
Objective: To distinguish clinical effects and mechanisms of sodium monofluorophosphate plus xylitol and herbal extracts of Swiss medicinal plants (Chamomilla recutita, Arnica montana, Echinacea purpurea, and Salvia officinalis). Materials and Methods: A 2-month-long comparative clinical study of toothpaste containing 1450 ppm sodium monofluorophosphate and xylitol (control, 15 patients) and toothpaste additionally containing extracts of the medicinal herbs (experiment, 35 patients) was performed on patients with gingivitis and the initial stage of periodontitis. Clinical indices of gingivitis/periodontitis were quantified by Loe & Silness’s, CPITN, OHI-S, and PMA indexes. The pro-inflammatory and anti-inflammatory interleukins, nitrites/nitrates, total antioxidant activity, and bacterial pattern characteristic for gingivitis and periodontitis were quantified in the gingival crevicular fluid and plaque. In the in vitro tests, direct anti-bacterial effects, inhibition of catalase induction in Staphylococcus aureus, in response to oxidative burst of phagocytes, and intracellular bacterial killing were determined for the toothpastes, individual plant extracts, and their mixture. Results: Experimental toothpaste was more efficient clinically and in the diminishing of bacterial load specific for gingivitis/periodontitis. Although the control toothpaste exerted a direct moderate anti-bacterial effect, herbal extracts provided anti-inflammatory, anti-oxidant, direct, and indirect anti-bacterial actions through inhibition of bacterial defence against phagocytes. Conclusions: Chemical and plant-derived anti-bacterials to treat gingivitis and periodontitis at the initial stage should be used in combination amid their different mechanisms of action. Plant-derived actives for oral care could substitute toxic chemicals due to multiple modes of positive effects.
Aim and Scope: The main task of dental implantation at the modern stage of its development remains the struggle against complications. At present, there is no generally accepted set of biomarkers and an algorithm for their use for early diagnosis of the risk of complications and monitoring of osseointegration. The objective of the study is to increase the effectiveness of dental implantation by developing a method of complex prophylaxis and prediction of development of complications in the long-term perspective after the operation. Materials and Methods: A method of preventing the development of complications of dental implantation by applying a complex of antioxidant vitamins and amino acids was approved and introduced. Results and Discussion: The significance of serum and local indices of the cytokine profile as diagnostic and prognostic parameters in patients with peri-implantitis developed afterthe operative intervention, was determined. It was found that patients with simultaneous installation of 5 or more implants, in spite of competent surgical work, are at higher risk of complications development in the long-term due to the presence of peculiarities of the mediator reaction with the prevalence of local inflammation processes. Conclusion: Perhaps a promising direction of prevention in the future will be the development of methods for targeted delivery of antioxidant substances to tissues to fill the deficit of protective components and establish an equilibrium.
The article discusses the method of treatment of chronic periodontitis using a dental gel containing NADH. The use of NADH for chronic periodontitis helps to eliminate inflammatory phenomena and stimulates the regeneration of the oral mucosa.
In the article results of mediator regulation of inflammatory processes in patients after one-sided (15 children) and reconstructive (15 children) rinocheiloplasty are presented. It is determined that in patients after reconstructive rinocheiloplasty at 57th day post operation antioxidant capacity of blood plasma is below normal values, that points on lack of compensatory increasing of anti-radical ferments. Specified deficit is necessary to be considered in conservative treatment by applying antioxidants.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.