The p-tau proteins in CSF come closest to fulfilling the criteria of a biological marker of AD. There is a tendency for p-tau proteins to perform differently in the discrimination of primary dementia disorders from AD.

No abstract

A series of 2,9-disubstituted-l,lO-phenanthroline type ligands have been used in palladiumcatalyzed displacement of allylic acetates. It was found that intermediate synand anti-(v3-buteny1)palladium complexes reacted with different rates and regiochemistries. Depending on the ligands, this could be used for regiocontrol as well as stereocontrol. With the parent 1,-10-phenanthroline, syn complexes were formed quickly as intermediates from both ( E ) and (2) allylic acetates, leading to nearly exclusive formation of (E) products. In contrast, complete retention of alkene stereochemistry was observed with 2,9-dimethyl-l,lO-phenanthroline which also gave a catalyst with a considerably higher activity than catalysts based on triphenylphosphine. @ (4) (a) Akermark, B.; Hansson, S.; Vitagliano, A. J. Am. Chem. SOC. 1990,112,4587. (b) Sjdgren, M.; Hansson, S.; Norrby, P.-0.; Akermark, B.; Cucciolito, M. E.; Vitagliano, A. Organometallics 1992, 11, 3954. (5) (a) Leutenegger, U.; Umbricht, G.; Fahrni, C.; von Matt, P.; Pfaltz, A.

Polycarboxylic acids and esters P 0253Iron-Catalyzed Nucleophilic Substitution of Allylic Acetate. -The iron-catalyzed alkylation of allylic acetates with sodium diethyl methylmalonate is more sensitive to steric effects than the corresponding palladium-catalyzed reaction: the substrate configuration, (Z) or (E), is retained in the displacement reactions. -(AAKERMARK*, B.; SJOEGREN, M. P. T.; Adv. Synth. Catal. 349 (2007) 17-18, 2641-2646; Dep. Org. Chem., Arrhenius Lab., Univ. Stockholm, S-106 91 Stockholm, Swed.; Eng.) -Bartels 15-054

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

S)-1-Phenylethylamine. -[ca. 30 refs.]. -(FEDERSEL*, H.-J.; HEDBERG, M.; QVARNSTROEM, F. R.; SJOEGREN, M. P. T.; TIAN, W.; Acc. Chem. Res. 40 (2007) 12, 1377-1384; Process Res. Dev., AstraZeneca R&D, S-151 85 Soedertaelje, Swed.; Eng.) -Lindner 17-233