SummaryA bioanalytical method using solid-phase extraction and high-performance liquid chromatography (LC) has been developed and validated for the determination of amocliaquine, chloroquine and their metabohtes in 100 ixL blood applied to sampling paper. The intra-assay precision for all analytes was < 5% at 2000 nM, < 7% at 750 nM and < 10% at 100 nM. The interassay precision for all analytes was < 4% at 2000 nM, < 7% at 750 nM and < 12% at 100 nM. The lower limit of quantitation was 100 nM for all analytes. The limit of detection was 30 nM in 100 ixLvenous blood applied to sampling paper.
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