This report includes six patients with femoral head fractures. Five were associated with posterior hip dislocation, of which one also had an ipsilateral trochanteric fracture. All were young adults who had been injured in automobile accidents. The protocol for management, indications for surgery and guidelines for evaluation of results are described.Résumé Présentation de 6 cas de fracture de la tête fé-morale. Cinq associaient à la fracture une luxation posté-rieure de la hanche et l'un d'eux associait aussi une fracture trochanterienne ipsilaterale. Tout les patients étaient de jeunes adultes blessés dans un accident de voiture. Le protocole de prise en charge,les indications de la chirurgie et les principes d'évaluation du résultat sont présen-tés.
Background:The rs3761548 polymorphism (3279 C> A) of the FOXP3 gene is associated with several autoimmune disorders. Its role in vitiligo has not been well studied.We sought to investigate whether rs3761548 polymorphism is associated with vitiligo in Egyptian subjects. Methods:Case-control study where genomic DNA was isolated from blood samples of 100 patients and 100 control subjects and genotyping was done by allele-specific primers. Given that FOXP3 is an X-linked marker, data analysis was done for the entire cohort and then stratified based on the gender. Results:The genotype frequencies differed significantly from patients to control subjects showing that AC genotype was significantly higher in the patient group than control subjects (risky genotype ) despite of the protective nature of CC genotype which observed in our study. According to the alleles , the A allele was higher in the patient than in the control group .Insignificant results were reported according to the association between FOXP3 (rs3761548) promoter polymorphism and clinical data of patients and their response to phototherapy.Conclusions: The rs3761548 of FOXP3 gene may be associated with susceptibility to vitiligo because of altered expression.Both the A allele and AC genotype were significantly associated with vitiligo .
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