Congenital microcephaly is not an optimal screening method for congenital Zika virus syndrome, because it may not accompany other evident and preceding brain findings; microcephaly could be an endpoint of the disease that results from progressive changes that are related to brain volume loss. Long-term studies are needed to understand the clinical and developmental relevance of these findings.
Compared to single-layer closure of spina bifida, three-layer closure preserves the fetal and obstetric benefits of fetoscopic repair, and shows reduced rate of cerebrospinal fluid leakage at birth and increased rate of reversal of hindbrain herniation 6 weeks postoperatively. What are the clinical implications of this work? Groups contemplating embarking on a program to offer fetoscopic repair of spina bifida should focus on performing a multilayer closure as opposed to a single-layer closure.
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