In the pharmaceutical industry, controlling the crystallization process of active pharmaceutical ingredients (API) is crucial to ensure chemical quality and physical properties. Process analytical technologies (PAT) provide a large number of tools that provide information in real-time to allow mastery of the final solid chain. In this paper is described how attenuated total reflection ultraviolet (ATR-UV) spectroscopy can be used to monitor concentration. Besides its classical application to UV-absorbing molecules, it will be shown how, in principle, it may be applied to molecules that do not absorb at UV wavelengths.
Abstract:In this paper, we detail how microantennae dedicated to Magnetic Resonance Imaging (MRI) can benefit from the advantages offered by polymer substrates, especially flexibility and dielectric properties. We present a monolithic and wireless design based on the transmission lines between conductor windings on both sides of a dielectric substrate and its fabrication process. This last one requires specific plasma treatments to improve polymer/metal adhesion. We have led a comparative study on the effects of the ageing time on the wettability and the metal adhesion to Kapton and Teflon surfaces. Correlation
OPEN ACCESSPolymers 2012, 4 657 between wettability (water contact angle) and adhesion (tensile strength) has been established. Then, the use of PolyDiMethylSiloxane (PDMS) as biocompatible packaging material and the optimization of its thickness allows us to conserve suitable f 0 and Q values in a conducting environment such as the biological tissues. These studies allow us to perform 7 Tesla in vivo MRI of the rat brain with a high spatial resolution of 100 x 100 x 200 µm 3 and a Signal to Noise Ratio of 80.
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