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Background: Infertility is a problem which affects one in six couples. However, male factor considers solely responsible in about 20% of infertile couples and contributory in another 30-40%. Objective: The aim of this study was to elucidate the effect of date palm pollen (DPP) and date palm seed extract (DPS) on cadmium-induced infertility in male rats. Materials and Methods: Thirty six male albino rats were divided into six groups (n=6) and received their treatment orally for 30 days: group 1, control; group 2, (DPP): (240mg/kg) daily, group 3, (DPS): (100mg/kg) daily, group 4, (CdCl 2): (5mg/kg) every other day, group 5, (CdCl 2 + DPP): CdCl 2 as group 4, followed by DPP as group 2 (each dose given 2 hours after CdCl 2); group 6, (CdCl 2 + DPS): CdCl 2 as group 4, followed by DPS as group 3 (each dose was given 2 hours after CdCl 2). Results: The current data exhibited significant decrease in the sperm quality, T, E2, FSH, LH, aromatase enzyme, TAC, GSH, SOD and CAT, with marked increase in MDA& XO and severe destruction in testis histoarchitecture in CdCl 2 treated rats. However, there was a significant improvement in all these parameters with DPP& DPS administration. Conclusion: consumption of DPP or DPS might be considered as a functional treatment for retarding risks of infertility associated with cadmium exposure.

The aqueous extract of Avicenna marina (AM) has been suggested to be useful in the treatment of various diseases. In this study, the protective effect of oral administration of Avicenna marina extract against oxidative gastric mucosal injury induced by nonsteroidal antiinflammatory drugs (NSAIDs), indomethacin in rats was investigated. The aqueous extract of Avicenna marina was given by oral gavages (125 mg /kg) three times at 12 h intervals before administering indomethacin (20 mg/kg).The level of prostaglandin (PGE2) and pH gradient were markedly decreased following indomethacin treatment, with increase in acid volume. In addition, tumor necrosis factor (TNFα), transforming growth factor-β1 (TGF-β1) and the lipid peroxidation products malondialdehyde (MDA) were significantly increased 6 h after oral administration of indomethacin in rats gastric mucosa indicating acute inflammatory injury.Pretreatment with AM abolished indomethacin induced elevation of TNF-α, TGF-β1 and MAD levels. In indomethacin-treated rats, the superoxide dismutase (SOD) and catalase (CAT) activities as well as reduced glutathione (GSH) content were significantly diminished in gastric mucosa. However, pre-administration with AM maintains the level of these parameters near to the control value. Thus, these results indicate the effective anti-peroxidative and preventive actions of AM against indomethacin-induced gastric mucosal damage.

Background: Diabetes is an imperative risk factor for cardiac complications development. Cleome droserifolia (Cd) is used in Egyptian traditional medicine for treatment of diabetes mellitus. Aim: The aim of the present study was to measure the possible protective effects of ethanolic extract of Cd against cardiacmyopathy in Streptozotocin (STZ) induced diabetic rats. Materials and Methods: Experimental diabetes was induced by intrapritoneal injection with a single dose of STZ (45 mg/kgbw). Oral dose Cd extract was administered daily for four weeks (310 mg/kg bw). Results: Diabetic rats exhibited an increase in glucose level and lipid profile as well as cardiacpro-inflammatory, pro-apoptotic markers and oxidative stress, while a decrease was recorded in antioxidant enzymatic activities. On the other hand the administration of diabetic rats with Cdextract for four weeks resulted in a significant amelioration in the most of the parameters mentioned above when compared with diabetic rats. Conclusion: The data clearly indicated that the treatment with Cleome droserifolia exerts a therapeutic protective nature in cardiac complications due to diabetes by decreasing oxidative stress and cardiac damage which may be attributed to its antioxidative potential.